Large cell type B primary testicular lymphoma: clinical, histopathological, therapeutic diagnosis and prognostic aspects
Abstract
Background: testicular lymphoma constitutes between 1 and 9 % of testicular tumors; it is the most frequent malignant testicular tumor in men over 50 years of age. The prognosis is reserved due to a great tendency to early systemic spread. The most common clinical presentation is testicular pain on palpation and spontaneous, with increased volume and testicular consistency. Its treatment is based on three fundamental pillars: orchiectomy, chemotherapy and radiotherapy.
Objective: to describe a patient with large cell type B testicular lymphoma.
Case report: 55-year-old male patient, hypertensive, smoker 10 cigarettes a day, occasional drinker. He goes to consultation due to left testicular volume increase. In the laboratory tests, the lactate dehydrogenase is elevated. Ultrasound Scand: Left testicle with very heterogeneous echogenicity, unstructured parenchyma, no nodular lesions. Diffuse thickening of the epididymis. Increased vascularization. Inguinal radical orchiectomy is performed, the anatomic-pathological diagnosis being diffuse large B cell type lymphoma, it has now been treated with chemotherapy, because he alsopresented bone involvement. But he has evolved favorably.
Conclusions: testicular lymphoma is a very rare entity, despite being considered the most common testicular tumor in people over 60 years of age. The majority are diffuse non-Hodgkin lymphomas of high intermediate degree of malignancy and immune-phenotype B. The prognosis is always reserved due to its great tendency to systemic spread. The treatment is based on surgery (radical inguinal orchiectomy), chemotherapy and radiotherapy.
DeCS: TESTICULAR NEOPLASMS/surgery; TESTICULAR NEOPLASMS/radiotherapy; LYMPHOMA, LARGE B-CELL, DIFFUSE/diagnosis; ORCHIECTOMY/methods; ANTINEOPLASTIC AGENTS /therapeutic use.
Downloads
References
1. Turner RR, Colby TV, Mackintosh FR. Testicular lymphomas: a clinicopathologic study of 35 cases. Cancer. 1981 Nov;48(9):2095-102.
2. Shahab N, Doll DC. Testicular lymphoma. Semin Oncol. 1999 Jun;26(3):259-269.
3. Brice P, De Kerviler E. Lymphomes de l'appareilurogenital. Ann Urol (Paris). 2007;41:1-5.
4. Cheah CY, Wirth A, Seymour JF. Primary testicular lymphoma. Blood [Internet]. 2014 [citado 21 Abr 2020];123(4):486-93. Disponible en: https://ashpublications.org/blood/article-lookup/doi/10.1182/blood-2013-10-530659
5. Izmr Guner S, Karacetin D, Yuksel M. Primary Testicular Diffuse Large B-Cell Lymphoma: A Case Report. World J Oncol [Internet]. 2013 [citado 21 Abr 2020];4(1):61-5. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649922/.
6. Mlika M, Chell YI, Benrhouma M, Haouet S, Horchani A, Zitouna MM, et al. A Primary Testicular Diffuse Large B-cell Lymphoma Belonging to the Germinal Center B-cell-like Group. J Clin Med Res [Internet]. 2010 [citado 21 Abr 2020];2(1):47-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299176/.
7. Gómez I, Rodríguez R, Sanz E, Rodríguez JM, Palmeiro A, Conde S, et al. Linfoma testicular primario: Aportación de un nuevo caso y revisión de la literatura. Actas Urol Esp [Internet]. 2004 [citado 21 Abr 2020];28(2):141-146. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0210-48062004000200011&lng=es
8. Delgado Bavai P, Abad Roger J, Bono Ariño A, Esclarin Duny M, Marigil Gomez, Sanz Velez JI. Linfoma testicular primario: Presentación de dos casos y revisión de la literatura. Arch Esp Urol [Internet]. 2008 [citado 21 Abr 2020];61(4):527-531. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0004-06142008000400011&lng=es
9. Ellatif M, Kumar R, Weller A, Katz D, Vrentzou E. Two Cases of Primary Testicular Lymphoma Presenting with Direct Spread along the Spermatic Cord and Gonadal Vessels. Case Rep Radiol [Internet]. 2019 [citado 21 Abr 2020];2019:5953618. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604472/.
10. Sabarwal KS, Ismail EHM. A case of primary testicular lymphoma with continuous spread along the gonadal vein and spermatic cord. BJR Case Rep [Internet]. 2019 Feb [citado 21 Abr 2020];5(1):20180063. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519503/.
11. Crellim AM, Vaughan Hudson BV, Bennett MH, Harland S, Vaughan Hudson G. Non-Hodgkins lymphoma of the testis. Radiother Oncol. 1993 May;27(2):99-06.
12. Morton LM, Slager SL, Cerhan JR, Wang SS, Vajdic CM, Skibola CF, et al. Etiologic heterogeneity among non-Hodgkin lymphoma subtypesprojet. J Natl Cancer Inst Monogr [Internet]. 2014 [citado 21 Abr2020];2014(48):130-44. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155467/.
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Elena Pérez-Rodriguez, Jesica del Pilar García-Pérez, José Alberto Hermida-Pérez, José Samuel Hernández-Guerra
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright: Camagüey Medical Archive Magazine, offers immediately after being indexed in the SciELO Project; Open access to the full text of the articles under the principle of making available and free the research to promote the exchange of global knowledge and contribute to a greater extension, publication, evaluation and extensive use of the articles that can be used without purpose As long as reference is made to the primary source.
Conflicts of interest: authors must declare in a mandatory manner the presence or not of conflicts of interest in relation to the investigation presented.
(Download Statement of potential conflicts of interest)
The Revista Archivo Médico de Camagüey is under a License Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 International (CC BY 4.0).
This license allows others to distribute, to mix, to adjust and to build from its work, even for commercial purposes, as long as it is recognized the authorship of the original creation. This is the most helpful license offered. Recommended for maximum dissemination and use of licensed materials. The full license can be found at: https://creativecommons.org/licenses/
22 julio 2025