Periodontal manifestations of acute myeloid leukemia: a case report

Authors

  • Clara Sonia Alayon Recio Clínica Estomatológica Martires de Pino Tres
  • Yamirka de la Caridad Rodríguez Guerra
  • Esperanza Zoe González Rodríguez
  • Reynaldo Enrique de León Heredia
  • Nismely Ayala Sotolongo

Keywords:

LEUCEMIAS, INFORMES DE CASOS, MUCOSITIS, HIPERPLASIA GINGIVAL

Abstract

Background: leukemia is considered a malignant neoplasm that is developed in the marrow bone. In this entity the inflammatory response in the presence of local irritants is higher and the defensive capacity is diminished. The specific diagnosis of leukemia demands a good interrogation, complete physical exam and detailed hematological studies.
Objective:
to present a case of acute myeloid leukemia which developed periodontal manifestations and to describe the treatment of leukemias.
Clinical case:
it is presented the case of a patient with loss of the generalized gingival morphology of spongy consistency, hipercolored, with a no painful increase in volume and that in some places covered the full crown of the teeth, ulcerated lesions, halitosis and submandibular lymphadenopathy. It was decided through the questioning and the periodontal clinical manifestations analysis, the remission of the patient to the Clinical Hematology Service, where laboratory tests were carried out, in addition it was confirmed the presence of acute myeloid leukemia and the patient was attended until he died.
Conclusions:
the dentists should know the periodontal manifestations of leukemia to carry out the convenient remission of the patient to a Service of Clinical Hematology, and to eliminate the local factors, the meticulous control of dental plaque, the regular professional cleaning and rinses with chlorhexidine with the purpose to alleviate the lesions in the mouth. The patient's physician should always be consulted before carrying out any treatment.
DeCS: PERIODONTAL DISEASES; LEUKEMIA, MYELOID, ACUTE; MUCOSITIS; GINGIVAL HYPERPLASIA; CASE REPORTS.

Downloads

Download data is not yet available.

Author Biography

Clara Sonia Alayon Recio, Clínica Estomatológica Martires de Pino Tres

Estomatóloga. especialista en Periodoncia. Profesor instructor.

References

1. Klokkevold P, Mealey B, Carranza F. Influence of sistemic disease and disorders on the periodontium. En: Newman M, Takei H, Carranza F, editors. Carranza's Clinical Periodontology . 9na ed. Philadelphia: Saunders Company; 2002. 217-38.

2. Linden GJ, Lyons A, Scannapieco FA. Periodontal systemic associations: review of the evidence. J Clin Periodontol [Internet]. 2013 [citado 2016 Jul 15];40(Suppl 14):[about 4 p.]. Available from: onlinelibrary.wiley.com/doi/10.1111/jcpe.12064/full

3. Linden GJ, Herzberg MC. Periodontitis and systemic diseases: a record of discussions. J Clin Periodontol [Internet]. 2013 [citado 2016 Jul 18];40(Suppl 14):[about 3 p.]. Available from: onlinelibrary.wiley.com/doi/10.1111/jcpe.12091/full

4. Santoyo Sánchez A, Ramos- Peñafiel C, Palmeros Morgado G, Mendoza García E, Olarte-Carrillo I, Martínez-Tovar A, et al. Leucemias agudas. Rev Med Inst Mex Seguro Soc [Internet]. Mar-Apr 2014 [citado 18 Jul 2016];52(2):[aprox. 6 p.]. Disponible en: www.medigraphic.com/pdfs/imss/im-2014/im142o.pdf

5. Perez Borrego A, Guntiñas Zamora MV, Garcia Romero J. Manifestaciones bucales en pacientes con Leucemias Agudas. Rev Haba Ciencias Médicas [Internet]. 2004 [citado 21 Oct 2005];3(8):[aprox. 9 p.]. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/679/511

6. He H, Yin J, Li X, Zhang Y, Xu X, Zhai M, et al. Association of ABCB1 polymorphisms with prognostic outcomes of anthracycline and cytarabine in Chinese patients with acute myeloid leukemia. Eur J Clin Pharmacol [Internet]. 2015 Mar [citado 2016 Jul 18];71(3):[about 6 p.]. Available from: link.springer.com/article/10.1007/s00228-014-1795-6

7. Goldman JM, Gale RP. What does MRD in leukemia really mean? Leukemia [Internet]. 2014 [citado 2016 Jul 18];28(5):[about 1 p.]. Available from: http://europepmc.org/abstract/med/24170026

8. Estey E, Othus M, Lee S J, Appelbaum FR, Gale RP. New drug approvals in acute myeloid leukemia: what’s the best end point? Leukemia [Internet]. 2016 [citado 2016 Sep 18];30(3):[about 5 p.]. Available from: www.nature.com/leu/journal/vaop/ncurrent/full/leu2015262a.html

9. Wang L, Hamard P, Nimer SD. PARP inhibitors: a treatment option for AML? Nature Medicine [Internet]. 2015 Dic [citado 2016 Sep 18];21(12):[about 2 p.] . Available from: www.nature.com/nm/journal/v21/n12/abs/nm.4007.html

10. Alibhai S, Breunis H, Timilshina N, Brignardello-Petersen R, Tomlinson G, Mohamedali H. Quality of life and physical function in adults treated with intensive chemotherapy for acute myeloid leukemia improve over time independent of age. J Geriatr Oncol [Internet]. 2015 Jul [citado 2016 Sep 18];6(4):[about 5 p.]. Available from: http://www.sciencedirect.com/science/article/pii/S1879406815000314

11. Wang L, Qin Y, Jia J, Zhao T, Wang J, Yang S. Clinical features and prognosis in MLL-AF10 positive acute leukemia. Zhonghua Xue Ye Xue Za Zhi [Internet]. 2015 Oct [citado 2016 Sep 18];36(10):[about 4 p.]. Available from: europepmc.org/abstract/med/26477762

12. Parwani S, Parwani RN. Diagnosis and management of focal reactive overgrowths of gingiva a case series. J Mich Dent Assoc [Internet]. 2014 Jul [citado 2016 Sep 20];96(7):[about 4 p.]. Available from: http://europepmc.org/abstract/med/25163184

13. Hadj Saïd M, Stroumsa R, Foletti JM, Chossegros C. An unusual case of gingival hyperplasia. Rev Stomatol Chir MaxillofacChir Orale [Internet]. 2014 Nov [citado 2016 Sep 20];115(5):[about 4 p.]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25001549

14. Van Montfort M, Huisman L. A woman with gingival hyperplasia. Ned Tijdschr Geneeskd [Internet]. 2014 [citado 2016 Sep 20];159:[about 1 p.]. Available from: http://europepmc.org/abstract/med/25589282

15. Choque Yapuchura JG. Leucemia Aguda, Manifestaciones Orales. Rev Act Clin Med [Internet]. Ene 2011 [citado 29 Jun 2016];4:[aprox. 1 p.]. Disponible en: http://revistasbolivianas.org.bo/scielo.php?script=sciarttext&pid=s230437682011000100006&Ing=es

16. He H; Yin J; Li X; Zhang Y; Xu X; Zhai M; et al. Association of ABCB1 polymorphisms with prognostic outcomes of anthracycline and cytarabine in Chinese patients with acute myeloid leukemia. Eur J Clin Pharmacol [Internet]. 2015 Mar [citado 2016 May 29];71(3):[about 7 p.]. Available from: link.springer.com/article/10.1007/s00228-014-1795-6

17. Van de Peppel RJ, Dekkers OM, Von dem Borne PA, de Boer MG. Relapsed and secondary disease drive the risk profile for invasive aspergillosis prior to stem cell transplantation in patients with acute myeloid leukemia or myelodysplastic syndrome. Med Mycol [Internet]. 2014 Oct [citado 2016 Jun 29];52(7):[about 7 p.]. Available from: mmy.oxfordjournals.org/content/52/7/699.short

18. Santana Garay JC. Atlas de patología del complejo bucal. La Habana: Editorial Científico-Técnica; 2010.

19. Van Dyke TE, Van Winkelhoff AJ. Infection and inflammatory mechanisms. J Clin Periodontol [Internet]. 2013 [citado 2016 Jun 29];40(Suppl 14):[about 7 p.]. Available from: onlinelibrary.wiley.com/doi/10.1111/jcpe.12088/full

20. Othus M, Appelbaum F, Petersdorf S, Erba H, Estey E. Evaluation of which patients get a second course of 3+7 on cooperative group trials for newly diagnosed acute myeloid leukemia: a report from SWOG. Blood [Internet]. 2013 [citado 2016 Jun 29];122(21):[about 1 p.]. Available from: http://www.bloodjournal.org/content/122/21/3925.short?sso-checked=true

21. Eley B, Soory M, Manson J. Efecto de los factores sistémicos sobre los tejidos periodontales. En: Eley B, Soory M, Manson J, editores. Periodoncia. 6ta ed. Ámsterdam: Elsevier; 2012. p. 107-23.

22. Santos Oliveira J dos, Ventiades JA, Fontana Lopes NN, Miranda França C. Dental care for pediatric patients with leukemia. Rev Cubana Estomatol [Internet]. 2004 [citado 2017 Ene 7];44(4):[about 4 p.]. Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75072007000400015&lng=es

23. Cuichán Meneses, CA. Estudio de las diferentes patologías bucales que se presentan en pacientes con leucemia en el Hospital de SOLCA de la ciudad de Guayaquil durante el año 2012-2013. Repositorio Universidad de Guayaquil [Internet]. Jul 2014 [citado 7 Ene 2017];[aprox. 48 p.]. Disponible en: http://repositorio.ug.edu.ec/handle/redug/6100

Published

2017-05-23

How to Cite

1.
Alayon Recio CS, Rodríguez Guerra Y de la C, González Rodríguez EZ, de León Heredia RE, Ayala Sotolongo N. Periodontal manifestations of acute myeloid leukemia: a case report. Arch méd Camagüey [Internet]. 2017 May 23 [cited 2025 Aug. 1];21(3):384-92. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/4886

Issue

Section

Case Reports