Alterations of the lipidic fraction in the patient burnings
Abstract
Introduction: The lipid alterations constitute a marker of bad forecast and in recent times it has run for candidate like biological marker in the evolution of the big burnt patients.
Objective: To determine the alterations of the lipid fraction in the burned patients.
Methods: An analytic, prospective and of longitudinal study was carried out for the sake of determining the alterations of the lipid fraction in the burned patient entered in the Hospital Universitario Manuel Ascunce Domenech of the city Camagüey, in the period understood since January of the 2019 to the month of February of 2022. They studied 30 patients in those who had into account variables: Severity rate, the figures of the serum cholesterol and of the triglycerides, the percent of corporal burned-out surface, the lipid patterns, the sepsis and the state to the medical release.
Results: The half a lower amounts of serum cholesterol and the figures the more tall stockings of triglycerides happened in those patients with over 30 percent of corporal burned-out surface. In the patients with severity rate of very severe, critic and the extreme critic was where lower the figures of cholesterol got registered. In the evolutionary periods of seven to 14 days the states of tall triglycerides met fundamentally very seriously ill patients' groups, and critic extreme with five patients in each group, what represents the 16.67 % and four critical patients for the 13.33 %. Of the total of the patients studied, in 13 of them a lipid pattern educated by cholesterol bass with tall triglycerides showed up, and 40 % of this group presented sepsis.
Conclusions: The great burned-out patients present important alterations in the metabolism of the lipids with unfavorable consequences in their evolution.
DeCS: BURNS; LIPID METABOLISM DISORDERS; PROGNOSIS; INPATIENTS; MORTALILY.
Downloads
References
1. Moya-Rosa EJ, Moya-Corrales Y. Complicaciones en los pacientes quemados. Arch méd Camagüey [Internet]. 2022 [citado 25 Feb 2023];26. Disponible en: https://revistaamc.sld.cu/index.php/amc/article/view/9306/4496
2. Smolle C, Cambiaso-Daniel J, Forbes AA, Wurzer P, Hundeshagen G, Branski LK, et al. Recent Trends in Burn Epidemiology Worldwide: A Systematic Review. Burns [Internet]. 2017 Mar [citado 19 Feb 2023];43(2):249–57. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5616188/
3. Rodríguez-Salazar OB, Lebrón-Matéo F, Fuentes-Díaz Z, Rodríguez- Hernández O. Evaluación del plasma rico en plaquetas para la cicatrización de los pacientes con quemaduras dérmicas. Arch méd Camagüey [Internet]. 2022 [citado 25 Feb 2023];26. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S1025-02552022000100032
4. Carrillo Esper R, Núñez Monroy FN. Dislipidemia en quemaduras graves. Rev Asoc Mex Med Crit y Ter Int [Internet]. 1999 [citado 25 Feb 2023];13(2):68-75. Disponible en: https://www.medigraphic.com/pdfs/medcri/ti-1999/ti992c.pdf
5. Moreira E, Burghi G, Manzanares W. Metabolismo y terapia nutricional en el paciente quemado crítico: una revisión actualizada. Med Intens [Internet]. 2018 Jun-Jul [citado 25 Ene 2023];42(5):306-16. Disponible en: https://www.medintensiva.org/es-metabolismo-terapia-nutricional-el-paciente-articulo-S0210569117302231
6. Auger C, Samadi O, Jeschke MG. The biochemical alterations underlying post-burns hypermetabolism. Biochim Biophys Acta [Internet]. 2017 Oct [citado 19 Feb 2023];1863(10):2633-44. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563481/
7. Yamano S, Shimizu K, Ogura H, Hirtose T, Hamasaki T, Shimazu T, et al. Low total cholesterol and high total bilirubin are associated with prognosis in patients with prolonged sepsis. J Crit Care [Internet]. 2016 Feb [citado 19 Feb 2023];31(1):36-40. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26596698/
8. Carrión Álvarez D. Hipocolesterolemia: Más allá de un valor de laboratorio. Rev ANACEM [Internet]. 2017 [citado 19 Ene 2023];11(2):4-5. Disponible en: https://docs.bvsalud.org/biblioref/2021/07/1123109/revista-anacem-112-9-10.pdf
9. Miquet Romero LM, Landaverde Hernández LO, Rodríguez Garcell RA, Escobar Vega H. Hipocolesterolemia en el paciente quemado [Internet]. 2016 [citado 25 Mar 2023]. Disponible en: https://www.medigraphic.com/pdfs/actamedica/acm-2016/acm162m.pdf
10. Garnica Escamilla MA, Lemus Sandoval J, Ramírez Martínez BN, Tamez Coyotzin EA, Marín Landa OM. Hipermetabolismo en el paciente quemado. Med Crit [Internet]. 2021 [citado 25 Ene 2023]. Disponible en: https://www.scienceopen.com/document?vid=5f4cd8cc-9401-44c2-8c1b-97aa8438d033
11. Miquet Romero LM, Escobar Vega H, Chávez Mondragón MA, Castañeda Prada A, Gutiérrez Rojas A, Posada Ruiz DA. Colesterol total sérico en la evolución del paciente quemado. Acta Médica [Internet]. 2020 [citado 25 Mar 2023];21(3):e75. Disponible en: http://www.revactamedica.sld.cu/index.php/act/article/view/75/pdf
12. Kraft R, Herndon DN, Finnerty CC, Hiyama Y, Jeschke MG. Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children. J Clin Endocrinol Metab [Internet]. 2013 Ene [citado 19 Ene 2023];98(1):314-21. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537101/
13. Lam NN, Khanh PQ, An NH. Characteristics And Outcome Influence Of Increased Plasma Triglyceride Level In Severely Burned Adult Patients. Ann Burns Fire Disasters [Internet]. 2021 Jun [citado 25 Ene 2023];34(2):145-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396158/
14. Jeyasuriya A, Badrinath AK, Nagalingam S. Cholesterol levels: the prognostic significance in ICU patients. IJAM [Internet]. 2018 May-Jun [citado 25 Ene 2023];5(3). Disponible en: https://www.ijmedicine.com/index.php/ijam/article/view/10
15. Jones TK, Wong HR, Meyer NJ. HDL Cholesterol: A Pathogen Lipid Sink for Sepsis? Am J Respir Crit Care Med [Internet]. 2019 Abr [citado 25 Ene 2023];199(7):812-14. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444663/
16. Coombes EJ, Batstone GF, Shakespeare PG, Levik PL. Lipid studies after burn injury in man. Burns [Internet]. 1979 Mar [citado 02 Mar 2023];5(3):265-68. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/0305417979900780
17. Khubchandan A, Shaikh MF, Gaadhe P. Study of alterations in Lipid profile after Burn injury. BJKines-NJBAS [Internet]. 2017 Jun [citado 05 Mar 2023];9(1). Disponible en: https://journals.indexcopernicus.com/api/file/viewByFileId/115229
18. Nabavi A, Allami A, Qasemi Barqi R. Changes in plasma lipid and in-hospital deaths in patients with sepsis. Med J Islam Repub Iran [Internet]. 2020 [citado 25 Ene 2023];34:45. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456431/
19. Barker G, Leeuwenburgh C, Brusko T, Moldawer L, Reddy ST, Guirgis FW. Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness. J Clin Med [Internet]. 2021 Abr [citado 25 Ene 2023];10(8):1693. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071007/
20. del Río Bazán D, Morera Pérez M, Díaz-Perera Fernández G. Valor pronóstico del colesterol en la morbilidad y mortalidad del paciente post operado grave. Revista Finlay [Internet]. 2021 [citado 15 Feb 2023];11(2). Disponible en: https://revfinlay.sld.cu/index.php/finlay/article/view/991/1990
Published
How to Cite
Issue
Section
License
Copyright: Camagüey Medical Archive Magazine, offers immediately after being indexed in the SciELO Project; Open access to the full text of the articles under the principle of making available and free the research to promote the exchange of global knowledge and contribute to a greater extension, publication, evaluation and extensive use of the articles that can be used without purpose As long as reference is made to the primary source.
Conflicts of interest: authors must declare in a mandatory manner the presence or not of conflicts of interest in relation to the investigation presented.
(Download Statement of potential conflicts of interest)
The Revista Archivo Médico de Camagüey is under a License Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 International (CC BY 4.0).
This license allows others to distribute, to mix, to adjust and to build from its work, even for commercial purposes, as long as it is recognized the authorship of the original creation. This is the most helpful license offered. Recommended for maximum dissemination and use of licensed materials. The full license can be found at: https://creativecommons.org/licenses/
22 julio 2025