Metabolic and mixed maternal variables, their relationship with uterine growth restriction
Keywords:
Restricción del crecimiento intrauterino, Variables maternas metabólicas, Variables maternas mixtas.Abstract
Background: intrauterine growth restriction is one of the main challenges of modern obstetrics, mainly in developing countries. Individuals who were victims of intrauterine growth restriction are biologically different, which includes a greater susceptibility to suffering from chronic diseases in adulthood.
Objective: to identify maternal, metabolic and mixed variables presumably related to intrauterine growth restrictions.
Methods: a transverse analytic study of pregnant women, who ended their pregnancy between September 2013 and October 2018 and whose newborns had intrauterine growth restriction was carried out in the Chiqui Gómez Lubián polyclinic of the municipality of Santa Clara. The sample was classified as small and adequate, according to trophic condition at birth. In each group, a relationship with metabolic and mixed variables, presumably related to the intrauterine restriction phenomenon, was studied.
Results: mothers of restricted children maintained normal values of metabolic variables upon uptake, but showed alteration of mixed variables.
Conclusions: intrauterine growth restriction could be related to the alteration of the mixed variables observed in their mothers.
DeCS: FETAL GROWTH RETARDATION /etiology; INFANT, SMALL FOR GESTATIONAL AGE; INFANT, LOW BIRTH WEIGHT; CROSS-SECTIONAL STUDIES; MULTIVARIATE ANALYSIS.
Downloads
References
1. Sadller TW. Langman. Embriologia Médica. 14 ed. Madrid: Wolters Kluwer; 2019.
2. Cunningham F, Leveno K, Bloom S, Dashe J, Hoffman B, Casey B, et al. Trastornos del crecimiento fetal. En: Whitridge W. Williams Obstetricia. 25 ed. México: McGraw-Hill Iberoamericana; 2019. p. 3.
3. Naranjo Logroño IE, Naranjo Coronel AA, Zumárraga Pozo CA, Peñaherrera Lema MB. Nutrients and Mother’s Diet in the Epigenetic Regulation of Placenta. ESPOCH Congresses: The Ecuadorian Journal of STEAM [Internet]. 2021 [citado 14 Ago 2021]; 1(6). Disponible en: https://knepublishing.com/index.php/espoch/article/view/9654
4. González Ballano I. Aumento ponderal materno en la gestación y su influencia en los resultados perinatales [Tesis Doctoral]. España: Universidad de Zaragoza; 2017 [citado 4 Feb 2021]. Disponible en: https://dialnet.unirioja.es/servlet/tesis?codigo=202250
5. Aguilera Méndez A. La nutrición materna y la programación metabólica: el origen fetal de las enfermedades crónicas degenerativas en los adultos. CIENCIA ergo-sum [Internet]. 2020 [citado 4 Feb 2021]; 27(3):[aprox. 7 p.]. Disponible en: https://cienciaergosum.uaemex.mx/article/view/12499/11395
6. Marciniak A, Patro-Małysza J, Kimber-Trojnar Ż, Marciniak B, Oleszczuk J, Leszczyńska-Gorzelak B. Fetal programming of the metabolic syndrome. Taiwan J Obstet Gynecol [Internet]. 2017 Abr [citado 4 Ene 2021]; 56(2): [aprox. 7 p.]. Disponible en: https://www.sciencedirect.com/science/article/pii/S1028455917300025
7. Blanco Pereira ME, Gonzáles Gil A, Luna Ceballos EJ, Almeida Torre L, Torres Del Valle FD, Bethencourt Herrera EA. Epigenética y ontogenia humana, baluarte inestimable en la promoción de salud y prevención de enfermedad. Rev Méd Electrón [Internet]. 2019 Jul-Ago [citado 4 Dic 2020]; 41(4):[aprox. 19 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1684-18242019000400959
8. Valdés Armenteros R, Ruiz Tellechea Y, Morilla Guzmán A, Domínguez Dieppa F, Montes López E, Camejo Plasencia A. Neonatología Diagnóstico y Tratamiento. La Habana: Editorial Ciencias Médicas; 2012.
9. Colectivo de Autores. Guías de actuación de las afecciones obstétricas frecuentes. La Habana: Editorial Ciencias Médicas; 2017.
10. Ma C-M, Lu N, Wang R, Liu X-L, Lu Q, Yin F-Z. Three novel obese indicators perform better in monitoring management of metabolic syndrome in type 2 diabetes. Sci Rep [Internet]. 2017 [citado 4 Nov 2020]; 7(1): [aprox. 5 p.]. Disponible en: https://www.nature.com/articles/s41598-017-10446-3
11. Ramírez Mesa C, Sarasa Muñoz NL, Cañizares Luna O, Álvarez-Guerra González E, Guillen Estévez AL, Mojena Roblejo M. Biometría fetal, condición trófica al nacer y factores de riesgo metabólicos maternos. Morfovirtual 2020 [Internet]. 2020 [citado 14 Ene 2021]:[aprox. 14 p.]. Disponible en: http://morfovirtual2020.sld.cu/index.php/morfovirtual/morfovirtual2020/paper/view/119
12. Kahn HS. The" lipid accumulation product" performs better than the body mass index for recognizing cardiovascular risk: a population-based comparison. BMC Cardiovasc Disord [Internet]. 2005 [citado 12 Feb 2020]; 5(1): [aprox. 26 p.].Disponible en: https://link.springer.com/article/10.1186/1471-2261-5-26
13. Bermúdez VJ, Salazar J, Añez R, Rivas Ríos JR, Chávez Castillo M, Torres W, et al. Optimal cutoff for visceral adiposity index in a Venezuelan population: Results from the Maracaibo City Metabolic Syndrome Prevalence Study. Rev Argent Endocrinol Metab [Internet]. 2017 [citado 26 Ene 2021]; 54(4): [aprox. 8 p.]. Disponible en: http://www.scielo.org.ar/pdf/raem/v54n4/v54n4a04.pdf
14. Gur EB, Ince O, Turan GA, Karadeniz M, Tatar S, Celik E, et al. Ultrasonographic visceral fat thickness in the first trimester can predict metabolic syndrome and gestational diabetes mellitus. Endocrine [Internet]. 2014 Nov [citado 4 Nov 2020]; 47(2): [aprox. 7 p.].Disponible en: https://pubmed.ncbi.nlm.nih.gov/24452873/
15. Bequer L, Gómez T, Molina JL, Freire C, Álvarez A, Quintero M, et al. Efecto de la Hiperglucemia pregestacional en la morfología fetal en un modelo de diabetes experimental. 1er Congreso Virtual CIBAMANZ [Internet]. 2020 [citado 26 Ene 2021]: [aprox. 13 p.]. Disponible en: http://www.cibamanz2020.sld.cu/index.php/cibamanz/cibamanz2020/paper/download/341/178
16. Catalano PM, Roman-Drago NM, Amini SB, Sims EA. Longitudinal changes in body composition and energy balance in lean women with normal and abnormal glucose tolerance during pregnancy. Am J Obstetr Gynecol [Internet]. 1998 Jul [citado 6 Ene 2021]; 179(1): [aprox. 11 p.]. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0002937898702674
17. Shalayel MH, Ahmed SA, Khattab AH, Satti GM. Frequency of Gestational diabetes mellitus and impaired glucose tolerance in urban Sudanese pregnant women in the third trimester. Sudan JMS [Internet]. 2012 Jun [citado 5 Nov 2020]; 7(2):[aprox. 4 p.]. Disponible en: https://www.ajol.info/index.php/sjms/article/view/88571
18. Catalano PM, Nizielski SE, Shao J, Preston L, Qiao L, Friedman JE. Downregulated IRS-1 and PPARγ in obese women with gestational diabetes: relationship to FFA during pregnancy. Am J Physiol-Endocrinol Metabol [Internet]. 2002 Mar [citado 5 Dic 2020]; 282(3):[aprox. 7 p.]. Disponible en: https://journals.physiology.org/doi/full/10.1152/ajpendo.00124.2001#
19. Rasmussen KM, Yaktine AL. Composition and components of gestational weight gain: physiology and metabolism. Weight Gain During Pregnancy: Reexamining the Guidelines [Internet]. Washington: National Academies Press; 2009 [citado 4 Nov 2020]:[aprox. 5 p.].. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK32815/
20. Okereke NC, Huston-Presley L, Amini SB, Kalhan S, Catalano PM. Longitudinal changes in energy expenditure and body composition in obese women with normal and impaired glucose tolerance. Am J Physiol-Endocrinol Metabol [Internet]. 2004 Sep [citado 11 Nov 2020]; 287(3): [aprox. 6 p.]. Disponible en: https://journals.physiology.org/doi/full/10.1152/ajpendo.00589.2003
Published
How to Cite
Issue
Section
License
Copyright: Camagüey Medical Archive Magazine, offers immediately after being indexed in the SciELO Project; Open access to the full text of the articles under the principle of making available and free the research to promote the exchange of global knowledge and contribute to a greater extension, publication, evaluation and extensive use of the articles that can be used without purpose As long as reference is made to the primary source.
Conflicts of interest: authors must declare in a mandatory manner the presence or not of conflicts of interest in relation to the investigation presented.
(Download Statement of potential conflicts of interest)
The Revista Archivo Médico de Camagüey is under a License Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 International (CC BY 4.0).
This license allows others to distribute, to mix, to adjust and to build from its work, even for commercial purposes, as long as it is recognized the authorship of the original creation. This is the most helpful license offered. Recommended for maximum dissemination and use of licensed materials. The full license can be found at: https://creativecommons.org/licenses/
22 julio 2025