Histological characterization of renal cell carcinoma

Authors

  • Patricia de los Milagros Springer Pérez Universidad de Ciencias Médicas de Camagüey
  • Boris Gustavo Suárez Sori
  • Oscar Figueredo García
  • Levin Torres Lebrato

Abstract

Background: the incidence of renal cancer increases worldwide and specifically in Cuba, which constitutes a serious health problem. Due to this, associated to the social and economic impact of the onset of the disease, it is necessary to characterize patients with renal cell cancer to identify the factors associated with their evolution and survival.
Objective: to characterize histopathologically renal cell carcinoma at "Manuel Ascunce Domenech" Hospital.
Methods: a cross-sectional descriptive study was conducted from September 2014 to June 2016. The universe consisted of 22 patients with renal cell cancer diagnosed at the aforementioned care and teaching institution, who met the inclusion criteria, with whom the research was carried out.
Results: clear cell carcinoma was predominant (68,2 %) followed by papillary carcinoma (22,7 %). The majority of patients presented tumors between 10 and 15 cm (68,2 %). Patients with grade III tumors were more frequent (45,5 %) followed by those with grade II tumors (22,7 %).
Conclusions: male patients aged between 55 and 64 years and white skin predominated. The most frequent associated factor was smoking. Most of the patients had low back pain, hematuria and palpable tumor as clinical manifestations. The most frequent tumor was clear cell carcinoma, with a size between 10 and 15 cm and stage III.
DeCS: CARCINOMA, RENAL CELL; LOW BACK PAIN; HEMATURIA; AGED; EPIDEMIOLOGY, DESCRIPTIVE.

Downloads

Download data is not yet available.

Author Biography

Patricia de los Milagros Springer Pérez, Universidad de Ciencias Médicas de Camagüey

Doctor en Médicina en 1986, Especialista de primer grado en Anatomía Patológica en 1990 y de segungo grado en 2006, Master en Humanidades Médicas en 2010, Profesor Auxiliar

References

1. Bins S, Lenting A, El Bouazzaoui S, van Doorn L, Oomen-de Hoop E, Eskens FA, et al. Polymorphisms in SLCO1B1 and UGT1A1 are associated with sorafenib-induced toxicity. Pharmacogenomics [Internet]. 2016 Sep [citado 2016 Aug 10];17(14):[about 2 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27533851

2. Hammers H. Immunotherapy in kidney cancer: the past, present, and future. Curr Opin Urol [Internet]. 2016 Nov [citado 2016 Aug 10];26(6):[about 6 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27533501

3. Naing A, Papadopoulos KP, Autio KA, Ott PA, Patel MR, Wong DJ, et al. Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors. J Clin Oncol [Internet]. 2016 Aug [citado 2016 Aug 10];15:[about 14 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27528724

4. Hacker KE, Fahey CC, Shinsky SA, Chiang YJ, DiFiore JV, Jha DK, et al. Structure/Function Analysis of Recurrent Mutations in SETD2 Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and H3K36 Trimethylation. J Biol Chem [Internet]. 2016 Sep [citado 2016 Aug 10];291(40):[about 9 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27528607

5. Schiavina R, Novara G, Borghesi M, Ficarra V, Ahlawat R, Moon D, et al. PADUA and RENAL nephrometry scores correlates with perioperative outcomes after robot-assisted partial nephrectomy: analysis of the Vattikuti Global Quality Initiative in Robotic Urologic Surgery (GQI-RUS) database. BJU Int [Internet]. 2016 Mar [citado 2016 Aug 10];119(3):[about 5 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27528265

6. Woo SM, Min KJ, Seo BR, Kwon TK. YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-kappaB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells. Oncotarget [Internet]. 2016 Sep [citado 2016 Aug 10];7(38):[about 6 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27528031

7. Koushyar S, Grant GH, Uysal-Onganer P. The interaction of Wnt-11 and signalling cascades in prostate cancer. Tumour Biol [Internet]. 2016 Aug 11 [citado 2016 Aug 10]:[about 6 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27514543

8. Jayasurya R, Srinivas BH, Ponraj M, Haridasan S, Parameswaran S, Priyamvada PS. Karyomegalic interstitial nephropathy following ifosfamide therapy. Indian J Nephrol [Internet]. 2016 Jul-Aug [citado 2016 Aug 10];26(4):[about 7 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/27512305

9. Haake SM, Weyandt JD, Rathmell WK. Insights into the Genetic Basis of the Renal Cell Carcinomas from The Cancer Genome Atlas. Mol Cancer Res [Internet]. 2016 Jul [citado 2016 Aug 10];14(7):[about 9 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27330105

10. Padevit C, Sauck A, John H. [Renal Cell Carcinoma: When is a Partial, Organ-preserving Nephrectomy Possible and Reasonable?]. Praxis [Internet]. 2016 Jun [citado 2016 Aug 10];105(13):[about 7 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27329708

11. Alpers CE, Chang A. Robbins and Cotran Pathologic Basis of Disease. 9a [Internet]. Philadelphia: Saunders; 2015 [citado 2016 Aug 10]. Available from: https://www.clinicalkey.es/#!/content/book/3-s2.0-B9781455726134000207

12. Frías Álvarez Gustavo. Uso combinado de inmunoterapia en paciente con carcinoma de células renales: nueve años después. Arch Med Camagüey [Internet]. Dic 2016 [citado 15 Mar 2017];20(6):[aprox. 6 p.]. Disponible en: http://scieloprueba.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552016000600010&lng=es

13. Bulnes Vázquez V, Álvarez Múgica M, Fernández Gómez JM, Nava Tomás E, Jalón Monzón A, Meilán Martínez Á. Características clínico-patológicas del carcinoma de células renales detectado incidentalmente mediante estudios radiológicos. Actas Urol Esp [Internet]. Nov-Dic 2008 [citado 10 Ago 2016];32(10):[aprox. 6 p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0210-48062008010000005&nrm=iso

14. Rodríguez Jasso VH, Serrano Brambila E, Maldonado Alcaraz E. Factores pronósticos en cáncer renal localizado y localmente avanzado. Actas Urol Esp [Internet]. Mar 2008 [citado 10 Ago 2016];32(3):[aprox. 5 p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0210-48062008003300009&nrm=iso

15. Giménez Bachs JM, Donate Moreno MJ, Salinas Sánchez AS, Pastor Navarro H, Carrión López P, Pastor Guzmán JM, et al. Supervivencia en relación a los factores pronóstico en una serie de pacientes con carcinoma de células renales. Arch Esp Urol [Internet]. Dic 2007 [citado 10 Ago 2016];60(10):[aprox. 4 p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0004-06142007010000004&nrm=iso

16. Ares Valdés Y. Correlación de los síntomas de los pacientes con cáncer de células renales con la supervivencia. Arch Esp Urol [Internet]. Abr 2009 [citado 10 Ago 2016];62(3):[aprox. 5 p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0004-06142009003300005&nrm=iso

17. Ma C, Lu B, Sun E. Clinicopathological and prognostic significance of survivin expression in renal cancer patients: a meta-analysis. Postgrad Med Journal [Internet]. 2016 Aug [citado 2016 Aug 10]:[about 8 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27489375

18. Venniyoor A, Essam AM, Ramadhan F, Keswani H, Mehdi I, Bahrani BA. High Occurrence of Non-Clear Cell Renal Cell Carcinoma in Oman. Asian Pac J Cancer Prev [Internet]. 2016 [citado 2016 Aug 10];17(6):[about 4 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27356693

19. Liu S, Chaudhry MR, Berrebi AA, Papadimitriou JC, Drachenberg CB, Haririan A, et al. Polyomavirus Replication and Smoking Are Independent Risk Factors for Bladder Cancer After Renal Transplantation. Transplantation [Internet]. 2016 May [citado 2016 Aug 10]:[about 9 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27232933

20. Alghamdi A, Alkhateeb S, Alghamdi K, Bazarbashi S, Murshid E, Alotaibi M, et al. Saudi Oncology Society and Saudi Urology Association combined clinical management guidelines for renal cell carcinoma. Urol Ann [Internet]. 2016 Apr-Jun [citado 2016 Aug 10];8(2):[about 4 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27141180

21. Bell RC, Austin ET, Arnold SJ, Lin FC, Walker JR, Larsen BT. Rare Leiomyoma of the Tunica Dartos: A Case Report with Clinical Relevance for Malignant Transformation and HLRCC. Case Rep Pathol [Internet]. 2016 [citado 2016 Aug 10]:[about 20 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27529047

22. Jalón Monzón A, Álvarez Múgica M, Fernández Gómez JM, Martín Benito JL, Martínez Gómez F, García Rodríguez J, et al. Adenocarcinoma de células renales: factores pronósticos y estadificación. Arch Esp Urol [Internet]. Mar 2007 [citado 10 Ago 2016];60(2):[aprox. 6 p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0004-06142007002200004&nrm=iso

23. Razafinjatovo C, Bihr S, Mischo A, Vogl U, Schmidinger M, Moch H, et al. Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance. BMC Cancer [Internet]. 2016 Aug [citado 2016 Aug 10];16(1):[about 8 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27530247

24. Rothermundt C, von Rappard J, Eisen T, Escudier B, Grunwald V, Larkin J, et al. Second-line treatment for metastatic clear cell renal cell cancer: experts' consensus algorithms. World J Urol [Internet]. 2016 Aug [citado 2016 Aug 10]:[about 5 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27488984

25. Liang L, Huang H, Dadhania V, Zhang J, Zhang M, Liu J. Renal cell carcinoma metastatic to the ovary or fallopian tube: a clinicopathological study of 9 cases. Hum Pathol [Internet]. 2016 May [citado 2016 Aug 10];51:[about 10 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27067787

26. Merseburger AS, Ljungberg B, Bex A. Renal cell carcinoma. World J Urol [Internet]. 2016 Aug [citado 2016 Aug 10];34(8):[about 3 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27401325

27. Medina López RA, Conde Sánchez JM, Congregado Ruiz CB, González Resina R, Mármol Navarro S, Torrubia Romero FJ. Factores pronósticos del carcinoma de células renales. Actas Urol Esp [Internet]. May 2009 [citado 10 Ago 2016];33(5):[aprox. 11 p.]. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0210-48062009005500116&nrm=iso

28. Otunctemur A, Dursun M, Ozer K, Horsanali O, Ozbek E. Renal Cell Carcinoma and Visceral Adipose Index: a new risk parameter. Int Braz J Urol [Internet]. 2016 Aug 18 [citado 2016 Aug 10];(1):[about 5 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27532115

Downloads

Published

2017-08-11

How to Cite

1.
Springer Pérez P de los M, Suárez Sori BG, Figueredo García O, Torres Lebrato L. Histological characterization of renal cell carcinoma. Arch méd Camagüey [Internet]. 2017 Aug. 11 [cited 2025 Jul. 15];21(4):452-60. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/5149

Issue

Vol. 21 No. 4 (2017)

Section

Original Articles

License

Copyright: Camagüey Medical Archive Magazine, offers immediately after being indexed in the SciELO Project; Open access to the full text of the articles under the principle of making available and free the research to promote the exchange of global knowledge and contribute to a greater extension, publication, evaluation and extensive use of the articles that can be used without purpose As long as reference is made to the primary source.

Conflicts of interest: authors must declare in a mandatory manner the presence or not of conflicts of interest in relation to the investigation presented.

(Download Statement of potential conflicts of interest)

The Revista Archivo Médico de Camagüey is under a License Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 International (CC BY 4.0).

This license allows others to distribute, to mix, to adjust and to build from its work, even for commercial purposes, as long as it is recognized the authorship of the original creation. This is the most helpful license offered. Recommended for maximum dissemination and use of licensed materials. The full license can be found at: https://creativecommons.org/licenses/