Porphyromonas gingivalis: influence on the effectiveness of periodontal therapy

Authors

  • Carlos Martín Ardila Medina Universidad de Antioquia
  • Alejandra Stephania Solarte Velasco
  • Isabel Cristina Guzmán Zuluaga

Abstract

Background: treatment protocols that include the combination of mechanical periodontal and antimicrobial therapy have shown greater clinical and microbiological efficacy compared to traditional mechanical therapy.
Objective: to evaluate the influence of basal porphyromonas gingivalis on clinical parameters of patients treated with moxifloxacin attached to traditional mechanical therapy in aggressive periodontitis.
Methods: an experimental study in treatment groups in which 40 patients were distributed in equitable way. One group received mechanical therapy plus moxifloxacin 400 mg systemically administered, once daily for seven days. Also, a control group received mechanical therapy and placebo, also once daily for seven days. Patients were randomly assigned to one of two study groups. Patients were evaluated clinically and microbiologically before periodontal therapy and six months after treatment.
Results: a higher increase was observed in clinical attachment level and greater reduction in probing depth in the group treated with moxifloxacin, with statistically significant differences favoring patients with presence of p. gingivalis at baseline. Multiple linear regression analysis showed that the presence of p. gingivalis at baseline was significantly associated with improved clinical parameters six months after therapy. The interaction p. gingivalis moxifloxacin was also significantly associated with a rise in clinical attachment level and probing depth decreased.
Conclusions: adjunctive moxifloxacin compared to traditional mechanical therapy leads to improved clinical benefits in patients with aggressive periodontitis harboring p. gingivalis.
DeCS: PORPHYROMONAS GINGIVALIS; PERIODONTITIS/THERAPY; ANTI-INFECTIVE AGENTS; CLINICAL PROTOCOLS; EPIDEMIOLOGY, EXPERIMENTAL

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Published

2016-08-10

How to Cite

1.
Ardila Medina CM, Solarte Velasco AS, Guzmán Zuluaga IC. Porphyromonas gingivalis: influence on the effectiveness of periodontal therapy. Arch méd Camagüey [Internet]. 2016 Aug. 10 [cited 2025 Aug. 1];20(4):425-31. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/4466

Issue

Vol. 20 No. 4 (2016)

Section

Original Articles

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