Survival of patients operated by advanced oral carcinoma according to post -surgical prognostic factors
Abstract
Introduction: The survival of patients operated on for advanced oral carcinoma depends on prognostic factors related to the patient, the tumor and the treatment.
Objective: To determine overall survival at 5 years and according to post-surgical prognostic factors in patients operated on for advanced oral cavity carcinoma.
Methods: A descriptive study was carried out on 88 patients with squamous cell carcinoma of the oral cavity in stages III and IVA, who received surgical treatment at the Conrado Benítez Oncological Hospital, between January 1st, 2019 and December 31st, 2023. The study population comprised all patients with stage III and IVA oral squamous cell carcinoma who underwent surgical treatment. The non-probabilistic and criterion-based sample included 88 patients. To achieve the proposed objective, the following variables were examined: survival time, tumor location, advanced ganglion condition, extra-ganglion extension, and number of adverse factors. For survival, the Kaplan-Meier method was applied. A value of p
Results: Patients with tumors located in the hard palate (five) and alveolar rim (eight), had a five-year survival of 100%. In contrast, none with tumors in the retromolar space survived. Those who were found to have an advanced ganglion condition and extra-nodal extension after surgery, survival was 21.2% and 24%, respectively. Single-factor, two-factor and three-factor survival were 50% and 35%, respectively, while the group with more than three adverse factors did not survive. Overall five-year survival was 65.2%.
Conclusions: Patients operated on for advanced oral cavity cancer had a high overall survival, although those patients with tumors located in the retromolar space and those with more than three adverse factors associated with them did not survive.
DeCS: SQUAMOUS CELL CARCINOMA OF HEAD AND NECK/surgery ; SQUAMOUS CELL CARCINOMA OF HEAD AND NECK/mortalily; SQUAMOUS CELL CARCINOMA OF HEAD AND NECK/rehabilitation; SURVIVORSHIP; PROGNOSIS.
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1. Ministerio de Salud Pública, Departamento Nacional de Estomatología. Programa Nacional de Atención Estomatológica a la Población [Internet]. La Habana: Editorial Ciencias Médicas; 2013. [citado 23 Feb 2024]. Disponible en: http://www.bvscuba.sld.cu/libro/programa-nacional-de-atencion-estomatologica-a-la-poblacion/
2. Dirección Nacional de Registros Médicos y Estadísticas de Salud. Ministerio de Salud Pública. Anuario Estadístico de Salud [Internet]. La Habana: Dirección Nacional de Registros Médicos y Estadísticas de Salud; 2022 [citado 8 Jun 2024]. Disponible en: https://files.sld.cu/dne/files/2023/10/Anuario-Estadistico-de-Salud-2022-Ed-20231.pdf
3.Barahona JB, Barquero M, Roselló M. Intervención paliativa de las limitaciones funcionales en la masticación y la deglución de las personas con cáncer de cavidad oral avanzado. Rev Terap [Internet]. 2022[citado 5 Sep 2022]; 16(1): 24-49. Disponible en: https://revistaterapeutica.net/index.php/RT/article/view/148
4.Torres Y, Rodríguez O, Rodríguez N, Viera KB, Díaz MJ, Marichal YA. Factores pronósticos del carcinoma epidermoide bucal. Mediciego [Internet]. 2020 [citado 23 Feb 2022]; 26(2):e1273. Disponible en: https://www.medigraphic.com/pdfs/mediciego/mdc-2020/mdc202g.pdf
5. González A. Estudio de supervivencia y recidiva del carcinoma epidermoide oral y de orofaringe [tesis]. Santiago de Compostela: Universidad de Santiago de Compostela; 2020 [citado 3 Mar 2022]. Disponible en: http://hdl.handle.net/10347/20739
6.Gallegos Hernández JF. Cáncer de cabeza y cuello. Su impacto en la historia de la humanidad. Gac Méd Méx [Internet]. 2020 [citado 1 Oct 2022];156(2): 104-109. Disponible en: https://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S0016-38132020000200104&lng=t
7. Pirola L. Evolución del cáncer de cabeza y cuello: segundas neoplasias y supervivencia [tesis]. Murcia: Universidad Católica de Murcia; 2023 [citado 3 Mar 2024]. Disponible en: https://repositorio.ucam.edu/bitstream/handle/10952/7637/pirolalaura_6307_583763_TFG%20LAURA%20PIROLA.pdf?sequence=1
8.Chiesa-Estomba CM, Soriano-Reixach M, Larruscain-Sarasola E. Predictive factors for simultaneous distant metastasis in head and neck cancer patients during the diagnostic work-up. Eur Arch Otorhinolaryngol [Internet]. 2021[citado 3 marzo 2024]; 278(11): 4483-4489. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33550436/
9.Lubov J, Labbé M, Sioufi K. Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review. J Otolaryngol Head Neck Surg [Internet]. 2021[citado 3 marzo 20245 3];50(1): 54. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34493343/
10.Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS. Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer. Int J Radiat Oncol BiolPhys [Internet]. 2019 [citado 3 marzo 2024]; 103(5):1109-1124.Disponible en: https://pubmed.ncbi.nlm.nih.gov/30562546/
11.Jiménez RY, Coca Granado RM. Factores pronósticos en el carcinoma epidermoide de cabeza y cuello. Acta Med Cent [Internet]. 2013 [citado 3 Mar 2024]; 7 (4): [aprox. 14 p.]. Disponible en: http://www.revactamedicacentro.sld.cu/index.php/amc/article/view/32
12.Caudell JJ, Gillison ML, Maghami E, Spencer S, Pfister DG, Adkins D; et al. NCCN Guidelines® Insights: Head and Neck Cancers, Version 1.2022. J Natl Compr Canc Netw Internet]. 2022 [citado 3 Mar 2024];20(3):224-234. Disponible en: https://pubmed.ncbi.nlm.nih.gov/35276673/
13.Cintra-Castro Y, Llerena-Suárez J, Casañola-Rivero O, Orea-Cordero I. Supervivencia de pacientes operados de neoplasias de cavidad oral estadio III y IV. Rev cuba otorrinolaringol cir cabeza cuello [Internet]. 2020 [citado 3 Mar 2024]; 4 (2). Disponible en: http://www.revotorrino.sld.cu/index.php/otl/article/view/158
14.Sánchez Villalón DR, Bory Porras L, Valdés Villafranca R, Cabrera Villar CL, Valdés Villafranca R. Supervivencia de los pacientes con tumores malignos avanzados de cavidad oral y laringe en el CAPO III Congreso de enero de 2014 a diciembre de 2018. Rev cuban oncol [Internet]. 2022 [citado 3 Mar 2024]; 20(1):[aprox. 2 p.]. Disponible en: http://revoncologia.sld.cu/index.php/onc/article/view/175
15.Oliveira L, Bergmann A, Melo A, Thuler LC. Factores pronósticos asociados con la supervivencia global en pacientes con carcinoma de células escamosas de la cavidad oral. Med oral [Internet]. 2021 [citado 3 Mar 2024];26(1): 22-30. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=7824547
16.Maraboli-Contreras S, Adorno-Farias D, Maturana-Ramirez A, Rojas-Alcayaga G, Fuentes-Alburquenque M, Espinoza-Santander I. Sobrevida de carcinoma oral de células escamosas: reporte de la Universidad de Chile. Rev Clin Periodoncia Implantol Rehabil Oral [Internet]. 2018 [citado 3 Mar 2024]; 11(3): 147-151. Disponible en: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0719-01072018000300147
17.Ghani W, Ramanathan A, Prime SS, Yang YH, Razak IA, Abdul Rahman ZA; et al. Survival of Oral Cancer Patients in Different Ethnicities. Cancer investigation [Internet]. 2019[citado 3 marzo 2024]; 37(7):275–287.Disponible en: https://pubmed.ncbi.nlm.nih.gov/31307249/
18.Kim DW, Lee S, Kwon S, Nam W, Cha IH, Kim HJ. Deep learning-based survival prediction of oral cancer patients. Scientific reports [Internet]. 2019 [citado 3 Mar 2024]; 9(1): 6994. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31061433/
19.Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I; et al. Survival outcomes after treatment of cancer of the oral cavity (1985-2015). Oral oncol [Internet]. 2019[citado 3 marzo 2024]; 90: 115–121. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30846169/
20.Thakar A, Thakur R, Kakkar A, Malhotra RK, Singh CA, SikkaK; et al. Oral Cancer in the Indian Subcontinent-Survival Outcomes and Risk Factors with Primary Surgery. Laryngoscope [Internet]. 2021[citado 3 marzo 2024]; 131(10): 2254–2261. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33797083/
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22 julio 2025