Nuclear Morphometric characterization of the healthy epidermis in patients with different ages and sex
Abstract
Introduction: The skin is a complex organ highly vulnerable to aging, a phenomenon that biologically causes changes at the tissue and cellular level. Usually the histological elements that characterize it are described with a qualitative approach, without taken age into account, however from the quantitative point of view, this aspect that morphometry makes possible has not been addressed in all its potentialities.
Objective: To characterize the behavior of morphometric indicators such as perimeter, area, nuclear volume in the cells of the spinous layer of the healthy epidermis, according to age and sex.
Methods: A case series study was carried out with 12 patients diagnosed with histopathology of basal cell carcinoma treated at the Oncology Center of the Provincial University Hospital Vladimir Ilich Lenin of Holguin, in the year 2019 and to which the tumor was removed by means of an excisional biopsy that included the lesion and a broad border of healthy skin. Theoretical and empirical methods were used, the latter based on techniques morphometric, then statistical analysis of the data obtained was performed and were reflected in tables.
Results: As age advances the nuclear perimeter, area, and volume decreased in both sexes.
Conclusions: Both the perimeter, the area and the nuclear volume decrease in the cell of the spinous layer of the healthy epidermis in both sexes as age advances, which translates into a decrease in nuclear size.
DeCS: EPIDERMIS; SKIN; SKIN AGING; CARCINOMA, BASAL CELL/pathology; CARCINOMA, BASAL CELL/therapy.
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22 julio 2025