Clinical and histopathological agreement of white lesions in the oral cavity
Abstract
Introduction: White lesions in the oral cavity constitute a health problem that responds to diverse causes and affects a considerable number of people worldwide. The conditions and results of the clinical diagnosis of lesions without a histopathological basis only show empirical deductions based on accumulated clinical experience, which may or may not agree with the real nature of the clinically diagnosed entity. The study of their concordance allows evidencing the certainty of the clinical diagnosis.
Objective: To determine the clinical and histopathological concordance of white lesions present in the oral cavity.
Methods: A cross-sectional descriptive observational study was carried out in 193 patients with white lesions in the oral cavity selected by non-probabilistic purposive sampling who attended the Department of Dentistry of the Arturo Puig Ruiz de Villa Polyclinic from January 2020 to January 2022. The lesions were biopsied to correlate the clinical diagnosis and histopathological diagnosis. The concordance of the results was evaluated using the Kappa index.
Results: The predominant age group was 40-49 years, the most affected patients were female and white skin color, the predominant lesion was leukoplakia with dysplasia, the most affected anatomical subsite was the cheek mucosa and more than half of the patients were related to smoking as a risk factor. The concordance strength of leukoplakia was very good with respect to lichen planus and hyperplastic chronic candidiasis (good). Squamous cell carcinoma had a moderate level of concordance.
Conclusions: The concordance results for white lesions present in the oral cavity in the 193 patients of the study were averaged and in general the study showed a good concordance.
DeCS: MOUTH/pathology; MOUTH/injuries; LEUKOPLAKIA, ORAL; SQUAMOUS CELL CARCINOMA OF HEAD AND NECK/diagnosis; SQUAMOUS CELL CARCINOMA OF HEAD AND NECK/pathology.
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1. Guerra Cobián O, Sarracent Pérez H, Urbizo Vélez J. Lesiones blancas de la cavidad bucal. Concordancia Diagnóstica. Rev haban cienc méd [Internet]. 2014 Oct [citado 14 Mar 2023];13(5):690-700. Disponible en: http://scieloprueba.sld.cu/scielo.php?script=sci_arttext&pid=S1729-519X2014000500006&lng=es
2. Donohue Cornejo A, de la Torre Morán A, de la Torre Morán G, Espinosa Cristóbal LF, Guzmán Gastelum DA, García Calderón AG, et al. Frecuencia de lesiones y condiciones orales en pacientes mayores de 18 años en una clínica de atención primaria en México. Int J Odontostomat [Internet]. 2018 Mar [citado 14 Mar 2023];12(1):129-33. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000100129&lng=es
3. Toledo Cabarcos Y, Suárez Sori B, Mesa López A, Albornoz López del Castillo C. Caracterización clínico e histopatológica de la leucoplasia bucal. Arch méd Camagüey [Internet]. 2018 Ago [citado 16 Mar 2023];22(4):432-51. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552018000400432&lng=es
4. Simi SM, Nandakumar G. White lesions in the oral cavity. A clinical histopathological study from a tertiary care dermatology centre in Kerala INDIA. Indian J Dermatol [Internet]. 2013 Jul [citado 18 Mar 2023];58(4):269-74. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726871/
5. Gil Milá JD, Maestre Cabello JR, Martínez Gómez K. Caracterización de pacientes con cáncer oral y su relación con la invasión en profundidad. Rev Finlay [Internet]. 2021 Dic [citado 22 Mar 2023];11(4):343-51. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S2221-24342021000400343&lng=es
6. Vázquez J, Secchi A, Astorga F, Moreno J, Amorín P. Lesiones en Mucosa Oral Pesquisadas en un Servicio de Urgencia Hospitalario. Int J Odontostomat [Internet]. 2022 Sep [citado 22 Mar 2023];16(3):370-76. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2022000300370&lng=es
7. Iparraguirre MF, Fajardo X, Carneiro E, Couto PH. Desórdenes orales potencialmente malignos-Lo que el odontólogo debe conocer. Rev Estomatol Herediana [Internet]. 2020 Jul [citado 24 Mar 2023];30(3):216-23. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1019-43552020000300216&lng=es
8. Figueroa Pérez Y, Pérez Aréchaga D, Borges García T, Ortiz Díaz LA, Cabrera García AG, Jiménez Rodríguez Y. Potencial de transformación maligna de las lesiones blanquecinas bucales. Rev Cub Med Mil [Internet]. 2021 Jun [citado 26 Mar 2023];50(2):e1071. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-65572021000200015&lng=es
9. Figueroa L, Tortone M, Gilligan G, Pánico R. Protocolo de follow-up en leucoplasia proliferativa multifocal para evitar progresión maligna. Presentación de un caso clínico. Odontoestomatología [Internet]. 2020 [citado 28 Mar 2023];22(36):94-102. Disponible en: http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-93392020000300094&lng=es
10. Warnakulasuriya S. Clinical features and presentation of oral potentially malignant disorders. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2018 [citado 01 Abr 2023];125(6):582-90. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S221244031830854X
11. Ñacato Llamuca MJ. Conocimientos sobre cáncer oral en estudiantes de Medicina y Odontología. Universidad Nacional de Chimborazo, 2022 [tesis]. Ecuador: Universidad Nacional de Chimborazo;2023 [citado 03 Abr 2023]. Disponible en: http://dspace.unach.edu.ec/handle/51000/10421
12. Werner LC, Piemonte ED. Lesiones bucales, factores de riesgo de cáncer bucal y autopercepción de irritación mecánica crónica en una campaña de prevención en la Ciudad de Buenos Aires. Rev Asoc Odontol Argent [Internet]. 2022 Abr [citado 03 Abr 2023];110(1):4-13. Disponible en: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S2683-72262022000100004&lng=es
13. Llanes Torres M, Díaz Rojas PA, Pérez Rumbaut GI, Crespo Lechuga GA, Naranjo Hernández L, Mesa Montero ZT. Parámetros histomorfométricos de la mucosa bucal en pacientes portadores de leucoplasia con displasia epitelial. Rev Finlay [Internet]. 2022 Jun [citado 05 Abr 2023];12(2):151-9. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S2221-24342022000200151&lng=es
14. Alvarez FM, Fortunato LP, Befani Bernal GA, Coto MB, Castellano LNB, Peralta MI. Leucoplasia verrucosa proliferativa: a propósito de un caso. Rev argent dermatol [Internet]. 2019 Dic [citado 05 Abr 2023];100(4):61-70. Disponible en: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-300X2019000400061&lng=es
15. Mendoza Robles JL, Martin Moya LA, Barreiro Mendoza N, Alcívar Cedeño V, Santos Zambrano TB. Leucoplasia verrugosa con asentamiento del virus papiloma humano subtipo 33. Reporte de un caso clínico. Revista San Gregorio [Internet]. 2020 [citado 07 Abr 2023];38:78-88. Disponible en: http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&pid=S2528-79072020000100078
16. Jarrín Ríos MA, Caicedo Breeddy MF, Garrido Villavicencio PR, Cepeda Inca HE. Terapia fotodinámica antimicrobiana sobre Candida albicans en superficies acrílicas de prótesis dentales. Estudio in vitro. Rev Eug Esp [Internet]. 2022 Dic [citado el 07 Abr 2023];16(3):72-82. Disponible en: http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&pid=S2661-67422022000300072&lng=en
17. Boza Oreamuno YV, López Soto A. Concordancia clínica e histopatológica de lesiones óseas orales. Estudio retrospectivo. Odovtos [Internet]. 2020 Dic [citado el 09 Abr 2023];22(3):163-73. Disponible en: http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S2215-34112020000300163&lng=en
18. Legrá Matos SM, Laplace Pérez BN, Martínez Pérez ML, Marrero Rivas R, López Rodríguez Y. Seguimiento de cinco años de la leucoplasia de la mucosa bucal en pacientes de Holguín. Correo cient méd [Internet]. 2017 Sep [citado 09 Abr 2023];21(3):776-85. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1560-43812017000300014&lng=es
19. Tatli U, Erdoğan Ö, Uğuz A, Üstün Y, Sertdemır Y, Damlar I. Diagnostic Concordance characteristics of oral cavity lesions. The Scientific World Journal [Internet]. 2013 Jun [citado 10 Abr 2023];2013. Disponible en: https://www.hindawi.com/journals/tswj/2013/785929/
20. Suliman NM, Astrom AN, Ali RW, Salman H, Johannessen AC. Oral mucosal lesions in skin diseased patients attending a dermatologic clinic: a cross-sectional study in Sudan. BMC Oral Health [Internet]. 2011 Mar [citado 12 Abr 2023];11(1):24. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187735
21. Angulo Núñez JJ, Rodríguez Archilla A. Lesiones de la mucosa bucal en pacientes de Mérida, Venezuela. Invest clín [Internet]. 2015 Dic [citado 13 Abr 2023];56(4):367-76. Disponible en: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332015000400004&lng=es
22. Mujica V, Rivera H, Carrero M. Prevalence of oral soft tissue lesions in an elderly venezuelan population. Med Oral Patol Oral Cir Bucal [Internet]. 2008 [citado 14 Abr 2023];13:e270-274. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/1844910
23. Patil P, Bathi R. Prevalence of oral mucosal lesions in dental patients with tobacco smoking, chewing, and mixed habits: A cross-sectional study in South India. J Family Community Med [Internet]. 2013 May [citado 14 Abr 2023];20(2):130-5. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748648/
24. Brouns E, Baart J. The relevance of uniform reporting in oral leukoplakia: Definition, certainty factor and staging based on experience with 275 patients. Med Oral Patol Oral Cir Bucal [Internet]. 2013 Jan [citado 18 Abr 2023];18(1):19. Disponible en: https://roderic.uv.es/handle/10550/35550
25. Gorsky M, Epstein J. Smoking Habits Among Patients Diagnosed with Oral Lichen Planus. Tob Induc Dis [Internet]. 2004 Jun [citado 20Abr 2023];2(2):103-08. Disponible en: https://link.springer.com/article/10.1186/1617-9625-2-2-103
26. Albornoz López del Castillo C, Zequeira Peña JL. Caracterización clínico-histopatológica del liquen plano bucal en las consultas de diagnóstico precoz del cáncer bucal. Arch méd Camagüey [Internet]. 2012 Ago [citado 20 Abr 2023];16(4):419-30. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552012000400007&lng=es
27. Rodríguez Lorenzo E, Osorio Núñez M, Morales Díaz R. Comportamiento de las lesiones bucales y sus factores de riesgo. Rev habanera cienc méd [Internet]. 2004 [citado 24 Abr 2023];3(10). Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/720

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