Uveal melanoma

Authors

  • Karell Piñón-García Universidad de Ciencias Médicas. Hospital Universitario Manuel Ascunce Domenech. Servicio de Anestesiología y Reanimación. Camagüey, Cuba. https://orcid.org/0000-0002-1336-1396
  • Yudelky Almeida-Esquivel Universidad de Ciencias Médicas. Hospital Universitario Manuel Ascunce Domenech. Departamento de Anatomía Patológica. Camagüey, Cuba. https://orcid.org/0000-0002-5413-0383
  • Yudenia Toledo-Cabarcos Universidad de Ciencias Médicas. Hospital Universitario Manuel Ascunce Domenech. Departamento de Anatomía Patológica. Camagüey, Cuba. https://orcid.org/0000-0002-5354-9414
  • Maurice José González-Basulto Universidad de Ciencias Médicas. Facultad de Tecnología de la Salud. Departamento de Imagenología y Radiofísica Médica. Camagüey, Cuba. https://orcid.org/0000-0003-4752-658X

Abstract

Introduction: Uveal melanoma is the most common intraocular cancer in adults, represents approximately 3 % to 5 % of all melanomas; with a peak incidence in men in the sixth decade of life.
Objective:
To describe the clinical presentation, diagnosis and treatment of a patient with uveal melanoma.
Case report:
A 39-year-old female patient, with a health history, who came to the consultation due to intense pain of twelve days of evolution located in the right eye, associated with loss of vision, pain with eye movements, asthenia and anorexy. Physical examination revealed severe palpebral edema, abundant mucopurulent secretions, marked 360-degree conjunctival chemosis, and cilio-conjunctival hyperemia in the right eye. Analytical and imaging studies were performed. When analyzing the results of the physical and complementary examination, the surgical intervention consisting of right orbital exenteration, sphenoidectomy and right transorbital ethmoidectomy was decided. With a satisfactory evolution, she was discharged from the hospital. Biopsy reported choroidal melanoma.
Conclusions:
Choroidal melanoma is a rare ocular entity in young black women. Symptomatology is extremely variable with choroidal masses. It is important to know its characteristics, since these clinical effects serve as a reminder for ophthalmologists to include it in the differential diagnosis of other ocular pathologies.

DeCS: PARANEOPLASTIC SYNDROMES, OCULAR/diagnosis; PARANEOPLASTIC SYNDROMES, OCULAR/surgery; MELANOMA; CHOROID NEOPLASMS; EYE ENUCLEATION.

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Author Biographies

Karell Piñón-García, Universidad de Ciencias Médicas. Hospital Universitario Manuel Ascunce Domenech. Servicio de Anestesiología y Reanimación. Camagüey, Cuba.

Especialista de Segundo Grado en Anestesiología y Reanimación. Investigador Agregado. Profesor Asistente. Universidad de Ciencias Médicas. Hospital Universitario Manuel Ascunce Domenech.

Yudelky Almeida-Esquivel, Universidad de Ciencias Médicas. Hospital Universitario Manuel Ascunce Domenech. Departamento de Anatomía Patológica. Camagüey, Cuba.

Especialista de Segundo Grado en Anatomía Patológica. Investigador Agregado. Instructor. Universidad de Ciencias Médicas. Hospital Universitario Manuel Ascunce Domenech.

References

1. Gajdzis M, Kaczmarek R, Gajdzis P. Novel Prognostic Immunohistochemical Markers in Uveal Melanoma-Literature Review. Cancers [Internet]. 2021 [citado 14 Ago 2022];13(16):4031. Disponible en: https://www.mdpi.com/2072-6694/13/16/4031

2. Nathan P, Hassel JC, Rutkowski P, Baurain JF, Butler MO, Schlaak M, et al. Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma. N Engl J Med [Internet]. 2021 Sep [citado 14 Ago 2022];385(13):1196-206. Disponible en: http://diposit.ub.edu/dspace/bitstream/2445/180520/3/NEJM2021Nathan.pdf

3. Menéndez-Hernández YC, O’Relly-Noda D, Cutiño-Hernández K, Pérez-Gutiérrez Y, Ribot-Ruiz LA. Panoftalmitis: presentación atípica de un melanoma coroideo. Rev med electrón [Internet]. 2022 Ene-Feb [citado 14 Ago 2022];44(1). Disponible en: http://scielo.sld.cu/scielo.php?pid=S1684-18242022000100227&script=sci_arttext&tlng=pt

4. Tsukikawa M, Akinpelu B, Wangaryattawanich P, Scherpelz K, Stacey AW. Uveal melanoma incidentally diagnosed with neuroimaging, a case series of 3 patients. Radiol Case Rep [Internet]. 2022 Ene [citado 14 Ago 2022];17(1):54-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572855/

5. Souri Z, Wierenga APA, Kroes WGM, Van der Velden PA, Verdijk RM, Eikmans M, et al. LAG3 and Its Ligands Show Increased Expression in High-Risk Uveal Melanoma. Cancers [Internet]. 2021 Sep [citado 14 Ago 2022];13(17):4445. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430821/

6. Singh M, Durairaj P, Yeung J. Uveal Melanoma: A Review of the Literature. Rev Oncol Ther [Internet]. 2018 [citado 14 Ago 2022];6:87-104. Disponible en: https://link.springer.com/article/10.1007/s40487-018-0056-8

7. Campos Alvergue S. Melanoma Coroideo: Reporte de Caso. Oftálmica [Internet]. 2021 Abr [citado 14 Ago 2022];20:20-4. Disponible en: http://pp.centramerica.com/pp/bancofotos/328-40608.pdf

8. Branisteanu DC, Bogdanici AM, Branisteanu DE, Maranduca IA, Zemba M, Balta F, et al. Uveal melanoma diagnosis and current treatment options (Review). Rev Experimental and therapeutic medicine [Internet]. 2021 [citado 14 Ago 2022];22(6):[aprox. 8 p.]. Disponible en: https://www.spandidos-publications.com/10.3892/etm.2021.10863

9. Fallico M, Raciti G, Longo A, Reibaldi M, Bonfiglio V, Ruso A, et al. Current molecular and clinical insights into uveal melanoma (Review). Intern J Oncol [Internet]. 2021 [citado 14 Ago 2022];10. Disponible en: https://www.spandidos-publications.com/ijo/58/4/10

10. Alemán Pérez A, Peñate Santana H, Rodríguez González F, Álvarez González E, Ogando González R, Alonso Pons V, et al. Melanoma coroideo. Caso clínico. Arch Soc Canar Oftalmol [Internet]. 2022 [citado 14 Ago 2022];33:100-3. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=8461815

11. Frattini Cuaranta V, Murcia Castillo Y, Clementti M, González Rota MC, Cazón P, Galmarini R. Desprendimiento de retina como signo de melanoma coroideo. Arch Argent Oftalmol [Internet]. 2022 [citado 14 Ago 2022];20(1). Disponible en: https://archivosoftalmologia.com.ar/index.php/revista/article/view/187

12. López-Martínez AL, Bautista-Hernández Y, Moreno-Páramo D. Melanoma coroideo: reporte de casos y experiencia del Hospital General de México. Gac Mex Oncol [Internet]. 2022 [citado 14 Ago 2022];21(Suppl):1-6. Disponible en: https://www.gamo-smeo.com/frame_eng.php?id=287

Published

2022-12-23

How to Cite

1.
Piñón-García K, Almeida-Esquivel Y, Toledo-Cabarcos Y, González-Basulto MJ. Uveal melanoma. Arch méd Camagüey [Internet]. 2022 Dec. 23 [cited 2025 Jul. 25];27:e9347. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/9347

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Section

Case Reports