Autologous fat grafting with lipofiltration in the nasolabial fold
Abstract
Introduction: The deepening of the nasolabial folds is one of the earliest signs of natural aging in humans and can be mitigated with the use of filler materials, including autologous fat grafting.
Objective: To describe the results of autologous fat infiltration in the nasolabial fold for facial rejuvenation.
Methods: An observational, descriptive, longitudinal and prospective study to describe the infiltration of autologous fat in the nasolabial fold for facial rejuvenation was carried out in 40 patients. The patients were followed up for 6 months: one month (1M), three months (3M) and six months (6M) and the evaluated variables were: recovery time, appearance of complications, degree of patient satisfaction and aesthetic results.
Results: The average age was 47 years, with a female prevalence. 92% of patients recovered in less than 10 days, with the only appearance of six complications. The decrease in the defect after the procedure was significant compared to the initial moment; however, over time (3-6M) the defect in the nasolabial fold reappeared in some patients. The degree of patient satisfaction varied between 95% (1M) to 90% at 6M and the aesthetic results classified as good decreased from 90% (1M) to 65% (6M).
Conclusions: It was shown that autologous fat grafting in the nasolabial fold is a procedure with good aesthetic results, however it decreases in subsequent months, which may be related to the reabsorption of the fat graft.
DeCS: NASOLABIAL FOLD; AGING; PLASTIC SURGERY PROCEDURES; FILTRATION; ABDOMINAL FAT.
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1. Erazo P. Cosmiatry, the science of beauty: why the plastic surgeon should know the non-surgical procedures. Cir plást Iberolatinoam [Internet]. 2020 Ene-Mar [citado 09 Jul 2021];46(1):3-6. Disponible en: https://scielo.isciii.es/pdf/cpil/v46n1/1989-2055-cpil-46-01-0003.pdf
2. Shue S, Kurlander DE, Guyuron B. Fat Injection: A Systematic Review of Injection Volumes by Facial Subunit. Aesthetic Plastic Surgery [Internet]. 2018 Oct [citado 09 Jul 2021];42(5):1261–70. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28791455/
3. Rabbani CC, Hwang MS, Byrne PJ, Desai SC. Management of Large Facial Defects. Facial Plast Surg. 2020; 36(2): 148-157. doi: 10.1055/s-0040-1709179.
4. Fernández Cossío S. Respuesta tisular a materiales de relleno [tesis doctoral]. Santiago de Compostela: Universidad de Santiago de Compostela; 2007 [citado 09 Jul 2021]. Disponible en: https://docplayer.es/13361221-Respuesta-tisular-a-materiales-de-relleno-estudio-experimental.html
5. Ueberreiter K. A Short History of Transplantation of Autologous Adipose Tissue. En: Ueberreiter K, editors. Autologous fat tissue transfer: Springer, Cham; 2019. p. 3-4.
6. Gentile P, Calabrese C, De Angelis B, Pizzicannella J, Kothari A, Garcovich S. Impact of the Different Preparation Methods to Obtain Human Adipose-Derived Stromal Vascular Fraction Cells (AD-SVFs) and Human Adipose-Derived Mesenchymal Stem Cells (AD-MSCs): Enzymatic Digestion Versus Mechanical Centrifugation. Int J Mol Sci [Internet]. 2019 [citado 09 Jul 2021];20(21):5471. Disponible en: https://www.mdpi.com/1422-0067/20/21/5471
7. Yang F, Ji Z, Peng L, Fu T, Liu K, Dou W, et al. Efficacy, safety and complications of autologous fat grafting to the eyelids and periorbital area: A systematic review and meta-analysis. PLoS One [Internet]. 2021 [citado 09 Jul 2021];16(4):e0248505. Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248505
8. Glogau RG. Physiologic and structural changes associated with aging skin. Dermatol Clin [Internet]. 1997 Oct [citado 09 Jul 2021];15(4):555-59. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0733863505704654
9. Carifio J, Perla RJ. Ten Common Misunderstandings, Misconceptions, Persistent Myths and Urban Legends About Likert Scales and Likert Response Formats and their Antidotes. J Social Science [Internet]. 2008 [citado 09 Jul 2021];3(3):106-16. Disponible en: https://thescipub.com/pdf/jssp.2007.106.116.pdf
10. Yu NZ, Huang JZ, Zhang H, Wang Y, Wang XJ, Zhao R, et al. A Systemic Review of Autologous Fat Grafting Survival Rate and Related Severe Complications. Chin Med J [Internet]. 2015 May [citado 09 Jul 2021];128(9):1245-51. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831554/
11. Innocenti A, Melita D, Innocenti M, The use of resected SMAS as autologous graft for the correction of nasolabial folds during rejuvenating procedures. Acta Biomed [Internet]. 2021 [citado 09 Jul 2021];92(5): e2021299. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689304/
12. Pelle-Ceravolo M, Angelini M. Properly Diluted Fat: An Easy and Safe Approach to Periocular Fat Grafting. Aesthetic Surgery J [Internet]. 2020 Ene [citado 09 Jul 2021];40(1):19-33. Disponible en: https://academic.oup.com/asj/article/40/1/19/5316139
13. Ruiz-Matta JM, Peniche-Castellanos A, Fierro-Arias L, Arellano-Mendoza MI, Ponce-Olivera RM. Aumento de mentón mediante implante de grasa autóloga abdominal. Dermatol Rev Mex [Internet]. 2017 May [citado 09 Jul 2021];61(3):190-96. Disponible en: https://dermatologiarevistamexicana.org.mx/article/aumento-de-menton-mediante-implante-de-grasa-autologa-abdominal/
14. Blanco Moredo E, Pereira Dávalos CI, Valdés Collazo C, Domínguez Sánchez Y. Deformidad facial: una discapacidad por su repercusión social. Archivos del Hospital Universitario General Calixto García [Internet]. 2017 [citado 09 Jul 2021];5(2). Disponible en: https://revcalixto.sld.cu/index.php/ahcg/article/view/229/202
15. Gutowski KA. Current applications and safety of autologous fat grafts: a report of the ASPS fat graft task force. Plast Reconstr Surg. 2009; 124(1): 272-280.
16. Romero-Álvarez F, Flores-Oseguera J, Argüello-Reyes J, Laínez-Mejía C. Lipoinfiltración en paciente con Síndrome de Parry-Romberg. Actual Med [Internet]. 2016 [citado 09 Jul 2021];101(797):38-40. Disponible en: https://digibug.ugr.es/bitstream/handle/10481/50575/797_38.pdf?sequence=1&isAllowed=y
17. Turin SY, Sinno S. High-Volume Lipofilling/Fat Transfer. New Methods, Techniques, and Technologies. What Is the Science? Adv Cosm Sur [Internet]. 2018 [citado 09 Jul 2019];1(1):133-141. Disponible en: https://www.clinicalkey.es/service/content/pdf/watermarked/1-s2.0-S254243271830016X.pdf?locale=es_ES&searchIndex
18. Planas J, Muñoz J, González D. Descripción de un nuevo sistema cerrado de procesamiento de grasa para la obtención de nanofat: análisis de resultados clínicos y citométricos. Cir plást iberolatinoam [Internet]. 2017 Ene-Mar [citado 09 Jul 2021];43(1): 23-32. Disponible en:
http://scielo.isciii.es/scielo.php?script=sci-arttext&pid=S0376-789220170001000004&Ing=es&tIng=es
19. Innocenti A, Melita D, Ghezzi S, Ciancio F. Extended Transconjunctival Lower Eyelid Blepharoplasty with Release of the Tear Trough Ligament and Fat Redistribution. Plast Reconstr Surg. 2018; 142(2): 235e-236e. doi: 10.1097/PRS.0000000000004555.
20. Cervilla Lozano JM, Cervilla Martín M. Blefaroplastia y corrección del surco nasolagrimal con grasa autóloga periorbitaria. Cir plást iberolatinoam [Internet]. 2019 Ene-Mar [citado 22 Feb 2023];45(1):19-26. Disponible en: https://scielo.isciii.es/pdf/cpil/v45n1/1989-2055-cpil-45-01-0019.pdf
21. Barnes CH, Maas CS. Autologous Fat Harvest and Preparation for Optimal Predictable Outcomes. Facial Plast Surg Clin North Am. 2019; 27(3): 419-423. Doi: 10.1016/j.fsc.2019.04.009.
22. Raj S, Abu-Ghname A, Davis MJ, Izaddoost SA, Winocour SJ. Safety and Regulation of Fat Grafting. Semin Plast Surg [Internet]. 2020 Feb [citado 09 Jul 2021];34(1):59-64. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023970/
23. Khorasani M, Janbaz P. Clinical evaluation of autologous fat graft for facial deformity: a case series study. J Korean Assoc Oral Maxillofac Surg [Internet]. 2021 Ago [citado 09 Jul 2021];47(4):286-90. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408649/
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