Undifferentiated pleomorphic soft tissue sarcoma: a case report
Abstract
Background: soft tissue sarcomas are aggressive tumors that can cause the death of patients, there are many histological types and can be located anywhere in the human body.
Objective: to report a patient with undifferentiated pleomorphic sarcoma in the right thigh region.
Case report: a 52-year-old white male patient with no morbid health history, who goes to the external Orthopedics and Traumatology clinic referring to have a little ball in the right thigh that has grown in the last month and it is accompanied by slight pain in the area. On physical examination, an increase in volume was observed at the level of the right thigh in the posterolateral area. On palpation, the tumor of irregular, bad-defined edges, mobile location below the fascia and hard consistency was checked. Taking into account all the previous elements, it is decided to take the patient to the operating room, for surgical treatment, where the tumor described above was extracted, it was sent to the Pathology department for histological study that revealed undifferentiated pleomorphic sarcoma with giant cells.
Conclusions: undifferentiated pleomorphic sarcoma is an uncommon soft tissue tumor with a poor prognosis. Symptoms and signs are more evident in the period of rapid growth. Imaging tests such as high definition ultrasound and magnetic resonance imaging are the main ones. The primary treatment of choice is surgery, followed by radio and chemotherapy.
DeCS: SARCOMA/diagnostic imaging; SARCOMA/surgery; THIGH/diagnostic imaging; SOFT TISSUE NEOPLASMS; CASE REPORTS.
Downloads
References
1. Spiguel A. Soft Tissue Sarcomas. En: Peabody TD, Attar S, editors. Orthopaedic Oncology. New York: Springer; 2014. p. 203-5.
2. Allen AH. Large undifferentiated pleomorphic sarcoma of the posterior thigh. Am J Case Rep [Internet]. 2019 Mar [citado 15 Sep 2021];20:318-22. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421979/.
doi: 10.12659/AJCR.914079
3. Matsumoto S. Changes in the diagnosis and treatment of soft tissue sarcoma in Japan,
1977-2016. J Orthop Sci [Internet]. 2018 May [citado 15 Sep 2021];23(3):441-8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29459081/.
doi: 10.1016/j.jos.2017.11.019
4. Wu CL, Lai YC, Wang HK, Chen PC, Chiou HJ. Correlation between histological and ultrasonographic findings of soft tissue tumors: to verify the possibility of cell-like resolution in ultrasonography. J Chin Med Assoc [Internet]. 2017 Nov [citado 15 Sep 2021];80(11):721-8. Disponible en: https://www.sciencedirect.com/science/article/pii/S1726490117302216
5. Lazarides AL, Kerr DL, Nussbaum DP, Kreulen RT, Somarelli JA, Blazer DG, et al. Soft tissue sarcoma of the extremities: what is the value of treating at high-volume centers? Clin Orthop Relat Res [Internet]. 2019 Abr [citado 15 Sep 2021];477(4):718-27. Disponible en: https://journals.lww.com/clinorthop/Fulltext/2019/04000/Soft_Tissue_Sarcoma_of_the_Extremities__What_Is.12.aspx
6. Cetinkaya OA, Celik SU, Kalem M, Basarir K, Koksoy C, Yildiz HY. Clinical characteristics and surgical outcomes of limb-sparing surgery with vascular reconstruction for soft tissue sarcomas. Ann Vasc Surg [Internet]. 2019 Abr [citado 15 Sep 2021];56:73-80. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0890509618308975?via%3Dihub
7. Mallinson PI, Chou H, Forster BB, Munk PL. Radiology of soft tissue tumors. Surg Oncol Clin N Am. 2014 Oct;23(4):911-36.
8. Jo VY, Doyle LA. Refinements in Sarcoma Classification in the current 2013 World Health Organization classification of tumours of soft tissue and bone. Surg Oncol Clin N Am. 2016 Oct;25(4):621-43. doi: 10.1016/j.soc.2016.05.001
9. Jakob J, Schmolders J. Systematic planning of surgery for soft tissue sarcoma of the extremities. Chirurg. 2019 Jun;90(6):441-6. doi: 10.1007/s00104-019-0921-5
10. Endo M, Lin PP. Surgical margins in the management of extremity soft tissue sarcoma. Chin Clin Oncol [Internet]. 2018 Ago [citado 15 Sep 2021];7(4):37. Disponible en: https://cco.amegroups.com/article/view/21033/20595
11. Bertucci F, Finetti P, Monneur A, Perrot D, Chevreau C, Le Cesne A, et al. PARP1 expression in soft tissue sarcomas is a poor-prognosis factor and a new potential therapeutic target. Mol Oncol [Internet]. 2019 Jul [citado 15 Sep 2021];13(7):1577-88. Disponible en: https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.12522
12. Charlson J. Selection of patients with localized extremity soft tissue sarcoma for treatment with perioperative chemotherapy. Curr Treat Options Oncol. 2018 Oct;19(12):65. doi: 10.1007/s11864-018-0586-1

Published
How to Cite
Issue
Section
License
Copyright: Camagüey Medical Archive Magazine, offers immediately after being indexed in the SciELO Project; Open access to the full text of the articles under the principle of making available and free the research to promote the exchange of global knowledge and contribute to a greater extension, publication, evaluation and extensive use of the articles that can be used without purpose As long as reference is made to the primary source.
Conflicts of interest: authors must declare in a mandatory manner the presence or not of conflicts of interest in relation to the investigation presented.
(Download Statement of potential conflicts of interest)
The Revista Archivo Médico de Camagüey is under a License Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 International (CC BY 4.0).
This license allows others to distribute, to mix, to adjust and to build from its work, even for commercial purposes, as long as it is recognized the authorship of the original creation. This is the most helpful license offered. Recommended for maximum dissemination and use of licensed materials. The full license can be found at: https://creativecommons.org/licenses/