Results of the cicatrization with bevacizumab in the age-related humid macular degeneration
Abstract
Background: the age-related macular degeneration is among the most common causes of harsh and irreversible visual loss in patient elders of 60 years in the industrialized world. Considering the increase of life expectancy and the rise in population of the senior citizens, the need of an early and opportune diagnosis, it is obvious for this disease that constitutes a health problem we have to solve.
Objective: to describe the results of the cicatrization with the use of the bevacizumab in the age-related humid macular degeneration.
Methods: a descriptive, longitudinal study in patients with the diagnosis of age-related humid macular degeneration was carried out. 25 patients that attended the retinal consultation in the period October, 2018 to April, 2019 and who fulfilled the criteria constituted the population of selection. They were applied an opinion poll and they studied variables were: Age, sex, pathological personal background, number of intravitreous injections placed to each patient, complications after injection and cicatrization of the macular injury. B
Results: according to the age groups and the sex, it was shown that the age between 60 and 69, ten patients and the feminine sex 15 patients were the most frequent. The ocular hypertension was the complication that predominated with four patients. The greatest amount of eyes healed with the administration of one and two doses of the medication.
Conclusions: the age group from 60 to 69 years and the feminine sex predominated. The ocular hypertension was the most frequent complication. It was verified high blood pressure as the most frequent pathological antecedent. The cicatrization of the eyes happened with the administration between one and two doses.
DeCS: MACULAR DEGENERATION/diagnosis; BEVACIZUMAB/therapeutic use; WOUND HEALING/drug effects; INTRAVITREAL INJECTIONS; OCULAR HYPERTENSION/complications.
Downloads
References
1. Boyd S. Degeneración macular relacionada con la edad. España: Jaypee-Highlights; 2012.
2. Klein R, Klein BE, Tomay SC, Meuer, Huang G. Ten year incidence and progression of age–related maculopathy: The Beaver Dam Eye Study. Ophthalmology. 2002;109(10):1767-79.
3. Leibowitz HM, Krueger DE, Maunder LR. The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration. Surv Ophthalmol. 1980;24(Suppl):335-610.
4. Zas M. Degeneración macular relacionada con la edad. Arch Argent oftalmol. 2008;79(3):48-9.
5. Naranjo Hernández Y, Figueroa Linares M, Cañizares Marín R. Envejecimiento poblacional en Cuba. Gac Méd Espirit [Internet]. Dic 2015 [citado 15 Abr 2020];17(3):[aprox. 10 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1608-89212015000300025&lng=es
6. National Eye Institute. Vision problems in the US: prevalence of adult visión impartiment and age-related disease in Americans. Maryland: Bethesida;2002.
7. Baguer Hernández R, Casado Triana I, Carrasco García MR, Cid Vásquez B. Características clínico epidemiológicas de la degeneración macular relacionada con la edad en un área de salud. GeroInfo. 2012;7(2):1-12.
8. Yates JR, Moore AT. Genetic susceptibility to age related macular degeneration. J Med Genet. 2000;37:83-7.
9. Fernández Aragón S. Degeneración Macular Asociada a la Edad (DMAE) y calidad de visión. Gaceta Artículo Científico. May 2017:1-10.
10. Lambert GN, Singh K M, ElShelmani H, Mansergh CF, Wride AM, Padilla M, et al. Risk Factors and Biomarkers of Age-Related Macular Degeneration. Prog Retin Eye Res. 2016 Sep;54:64–102.
11. Hyman L, Schatat AP, He Q, Leske MC. Hypertension, cardiovascular disease, and age-related macular degeneration. Arch Ophthalmol. 2000; 118:351-58.
12. Domínguez Fernández R, Pérez Domínguez R, Sánchez Ferreiro AV. Actualización en degeneración macular asociada a la edad. Tthea Info [Internet]. 2014 [citado 15 Abr 2020];(69):[aprox. 23 p.]. Disponible en: www.laboratoriosthea.com/publicaciones/thea-informacion
13. Gass JDM. Drusen and disciform macular detachment and degeneration. Arch Ophthalmol. 1973;90:206-17.
14. Nunes RP, Rosenfeld PJ, de Amorim Garcia Filho CA, Yehoshua Z, Martidis A, Tennant TS. Age-related macular degeneration. En: Yanoff M, Duker JS, editores. Ophthalmology. 4th ed. Philadelphia, PA: Elsevier Saunders; 2014. p.6-28.
15. Kanski JJ, Bowling B. Oftalmología clínica. 7ª ed. Barcelona: Elsevier; 2012.
16. Yonekawa Y, Kim IK. Clinical characteristics and current treatment on age-related macular degeneration. Cold Spring Harb Perspect Med. 2015;5(1):a017-178.
17. American Academy of Ophthalmology. Preferred Practice Pattern: Age-related macular degeneration [Internet]. San Francisco, CA: American Academy; 2015 [actualizado 22 Sep 2015; citado 18 Oct 2019]:[aprox. 2 p.]. Disponible en: http://www.aao.org/preferred-practice-pattern/age-related-macular-degeneration-ppp-2015
18. American Academy of Ophthalmology. Age-related macular degeneration [Internet]. San Francisco, CA: American Academy; 2019 [actualizado 17 Sep 2015; citado 18 Oct 2018]:[aprox. 2 p.]. Disponible en: http://www.geteyesmart.org/eyesmart/diseases/amd.cfm
19. Monje Fernández L, Dolz Marco R, Andreu Fenoll M, Fornés Ferrer V, Gallego Pinazo R. Incidencia y resultados clínicos de las distintas formas neovasculares de degeneración macular asociada a la edad en Valencia (España). Arch Soc Esp Oftalmol. 2018; 93(7):324-28.
20. Wormald R, Evans J, Smeeth L, Henshaw K. Photodynamic therapy for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD002030.
21. Hooper CY, Guymer RH. New treatments in age-related macular degeneration. Clin Exp Ophthalmol. 2003 Oct;31(5):376-91.
22. González Castellanos ME, Espósito E, Crim N, Correa L, Martínez D, Barros-Centeno MF, et al. Bevacizumab intravítreo en el tratamiento de las oclusiones venosas de la retina. Rev Methodo [Internet]. 2017 [citado 15 Abr 2020];2(2):59-64. Disponible en:
http://methodo.ucc.edu.ar/index.php/methodo/article/view/35
23. Dana Martínez M, González-Castellanos E, Barros Centeno MF, Correa L, Guantay CD, Serra HM, et al. Bevacizumab intravítreo como tratamiento de maculopatías miópicas neovasculares. Rev Methodo [Internet]. 2017 [citado 15 Abr 2020];2(2):55-58. Disponible en: http://methodo.ucc.edu.ar/index.php/methodo/article/view/34
24. Sánchez Vicente JL, Muñoz Morales A, Galván Carrasco MP, Castilla Lázpita A, Vital Berral C, Alfaro Juárez A, et al. Bevacizumab intravítreo en el tratamiento de la maculopatía por radiación. Arch Soc Esp Oftalmol. 2017;92:283-86.
25. Maguire JI. Age-related macular degeneration. En: Gault JA, Vander JF, editores. Ophthalmology Secrets in Color. 4th ed. Philadelphia, PA: Elsevier; 2015.p.300-10.
26. Harrison Gómez C, Domínguez Carrillo LG. Degeneración macular relacionada con la edad. Acta méd Grupo Ángeles [Internet]. Dic 2017 [citado 15 Abr 2020];15(4):[aprox. 1 p.]. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-72032017000400312&lng=es
27. Rio Torres M, Fernández Argones EL, Hernández Silva JR, Ramos López M. Oftalmología, diagnóstico y tratamiento. Sección VI Retina [CD-ROM]. La Habana: Editorial Ciencias Médicas; 2018.
28. Berg K, Pedersen TR, Sandvik L, Bragadottir R. Comparison of ranibizumab and bevacizumab for neovascular age-related macular degeneration according to LUCAS treat-and-extend protocol. Ophthalmology. 2015;122(1):146-52.
29. Schmucker Cl, Loke YK, Ehlken C, Agostini HT, Hansen LL, Antes G, et al. Intravitreal bevacizumab (Avastin) versus ranibizumab (Lucentis) for the treatment of age related macular degeneration: a safety review. Br J Ophthalmol. 2011;95:308-17.
30. Caballero Abdala C, Fonseca Rodriguez D, Nieto Moreno A, Tuesca R. Evaluación de los cambios en la presión intraocular luego de inyección intravítrea de antiangiogénicos. Rev Soc Colomb Oftalmol. 2014;47(4):294–302.
Published
How to Cite
Issue
Section
License
Copyright: Camagüey Medical Archive Magazine, offers immediately after being indexed in the SciELO Project; Open access to the full text of the articles under the principle of making available and free the research to promote the exchange of global knowledge and contribute to a greater extension, publication, evaluation and extensive use of the articles that can be used without purpose As long as reference is made to the primary source.
Conflicts of interest: authors must declare in a mandatory manner the presence or not of conflicts of interest in relation to the investigation presented.
(Download Statement of potential conflicts of interest)
The Revista Archivo Médico de Camagüey is under a License Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 International (CC BY 4.0).
This license allows others to distribute, to mix, to adjust and to build from its work, even for commercial purposes, as long as it is recognized the authorship of the original creation. This is the most helpful license offered. Recommended for maximum dissemination and use of licensed materials. The full license can be found at: https://creativecommons.org/licenses/
22 julio 2025