Carcinoid tumor of the duodenum: a rare and interesting incidental finding

Authors

Keywords:

tumores neuroendocrinos gastrointestinales, tumor carcinoide de duodeno, cromogranina.

Abstract

Background: duodenal carcinoid tumor is rare; it represents 2% of gastrointestinal neuroendocrine tumors. Therefore, a case of this is presented, recently diagnosed at the Joaquín Albarrán Clinical Surgical Hospital in Havana.
Objective:
to report a case of carcinoid tumor of the duodenum and review the literature with emphasis on the histopathological diagnosis.
Clinical case:
86-year-old male patient who died on the fifth day after admission. At autopsy, during the macroscopic examination of the intestines, a lesion was revealed at the level of the first portion of the duodenum which, due to its histopathology, corresponded to a carcinoid tumor of the duodenum.
Conclusions:
duodenal carcinoid is a rare tumor whose endoscopic or histological diagnosis is made incidentally in the vast majority of cases; it is generally associated with a benign progression, although endoscopic removal of tumors smaller than 1 cm without periampullary location or evidence of invasion of the muscular layer is recommended, evaluated by histology or endoscopic ultrasound.

DeCS: CARCINOID TUMOR/diagnosis; DUODENUM/pathology; ENDOSONOGRAPHY; CASE REPORTS; NEUROENDOCRINE TUMORS/diagnosis.

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References

1. Hallet J, Lim Law CH, Cukier M, Saskin R, Liu N, Singh S. Exploring the rising incidence of neuroendocrine tumors: a population-based analysis of epidemiology, metastatic presentation, and outcomes. Cancer. 2015;121(4):589–97.

2. Howe JR, Cardona K, Fraker DL, Kebebew E, Untch BR, Wang YZ, et al. The Surgical Management of Small Bowel Neuroendocrine Tumors: Consensus Guidelines of the North American Neuroendocrine Tumor Society (NANETS). Pancreas [Internet]. 2017 [citado 20 Oct 2020];46(6):715–731. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502737/.

3. Ito T, Igarashi H, Nakamura K, Sasano H, Okusaka T, Takano K, et al. Epidemiological trends of pancreatic and gastrointestinal neuroendocrine tumors in Japan: a nationwide survey analysis. J Gastroenterol [Internet]. 2015 [citado 20 Oct 2020];50:58–64. Disponible en: https://link.springer.com/article/10.1007/s00535-014-0934-2

4. Mairena Valle MA. Carcinoide duodenal: reporte de un caso. Endoscopia [Internet]. 2016 [citado 20 Oct 2020];28(4):181-183. Disponible en: https://www.sciencedirect.com/science/article/pii/S018898931630094X

5. Sato Y. Endoscopic diagnosis and management of type I neuroendocrine tumors. World J Gastrointest Endosc [Internet]. 2015 [citado 20 Oct 2020];7(4):346–353. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400623/.

6. Öberg K, Lamberts SW. Somatostatin analogues in acromegaly and gastroenteropancreatic neuroendocrine tumours: past, present and future. Endocr Relat Cancer [Internet]. 2016 [citado 20 Oct 2020];23(12):R551-R566. Disponible en: https://erc.bioscientifica.com/view/journals/erc/23/12/R551.xml

7. Blažević A, Hofland J, Hofland LJ, Feelders RA, de Herder WW. Small intestinal neuroendocrine tumours and fibrosis: an entangled conundrum. Endocr Relat [Internet]. 2018 [citado 20 Oct 2020];25(3):R115-R130. Disponible en: https://erc.bioscientifica.com/view/journals/erc/25/3/ERC-17-0380.xml

8. Pasricha G, Padhi P, Daboul N, Monga DK. Management of Well-differentiated Gastroenteropancreatic Neuroendocrine Tumors (GEPNETs): A Review. Clin Ther [Internet]. 2017 [citado 20 Oct 2020];39(11):2146-2157. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S0149-2918(17)31016-0

9. Niederle B, Pape UF, Costa F, Gross D, Kelestimur F, Knigge U, et al. ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum. Neuroendocrinology [Internet]. 2016 [citado 20 Oct 2020];103:125–138. Disponible en: http://www.grupponet.it/Documenti/14-Jejunum%20and%20ileum%20ENETS%202016.pdf

10. Daskalakis K, Tsolakis AV. Upfront surgery of small intestinal neuroendocrine tumors. Time to reconsider? World J Gastroenterol [Internet]. 2018 [citado 20 Oct 2020];24(29):3201-3203. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079287/.

11. Jensen RT, Norton JA, Oberg K. Neuroendocrine Tumors. En: Feldman M, Friedman LS, Brandt LJ, editors. Sleisenger and Fordtran’s Gastrointestinal and Liver Diseases. 10th ed. Philadelphia: Elsevier Saunders; 2016. p.501–541.

12. Campana D, Ravizza D, Ferolla P, Faggiano A, Grimaldi F, Albertelli M, et al. Risk factors of type 1 gastric neuroendocrine neoplasia in patients with chronic atrophic gastritis. A retrospective, multicentre study. Endocrine [Internet]. 2017 [citado 20 Oct 2020];56(3):633-638. Disponible en: https://link.springer.com/article/10.1007%2Fs12020-016-1099-y

13. Blasco MC, Boselli FG, Blasco C. Tumor carcinoide: a propósito de dos casos clínicos. Rev Gastroenterol Perú [Internet]. 2016 [citado 20 Oct 2020];36(3):[aprox. 6 p.]. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1022-51292016000300014&lng=es&nrm=iso

14. Waisberg J, Joppert-Netto G, Vasconcellos C, Sartini GH, Miranda LS, Franco MI. Carcinoid tumor of the duodenum: A Rare Tumor At An Unusual Site. Case series from a single institution. Arq Gastroenterol [Internet]. 2013 [citado 20 Oct 2020];50(1):3-9. Disponible en: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032013000100003&lng=en

15. Kim GH, Kim JI, Jeon SW, Moon JS, Chung IK , Jee SR, et al. Korean College of Helicobacter and Upper Gastrointestinal Research Endoscopic resection for duodenal carcinoid tumors: A multicenter, retrospectiv e study. J Gastroenterol Hepatol [Internet]. 2014 [citado 20 Oct 2020];29(2):318-324. Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/jgh.12390

16. Tsai SD, Kawamoto S, Wolfgang CL, Hruban RH, Fishman EK. Duodenal neuroendocrine tumors: retrospective evaluation of CT imaging features and pattern of metastatic disease on dual-phase MDCT with pathologic correlation. Abdom Imaging [Internet]. 2015 [citado 20 Oct 2020];40(5):1121–1130. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450119/.

17. Mullen JT, Wang H, Yao JC, Lee JH, Perrier ND, Pisters PW, et al. Carcinoid tumors of the duodenum. Surgery [Internet]. 2005 [citado 20 Oct 2020];138:971-7. Disponible en: https://www.surgjournal.com/article/S0039-6060(05)00564-7/fulltext

18. Zúñiga MD. Tumores neuroendocrinos gastrointestinales. Med leg Costa Rica [Internet]. 2013 [citado 20 Oct 2020];30(1):89-98. Disponible en: http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409-00152013000100012&lng=en

19. Nikou GC, Toubanakis C, Moulakakis KG, Pavlatos S, Kosmidis C, Mallas E, et al. Carcinoid tumors of the duodenum and the ampulla of Vater: current diagnostic and therapeutic approach in a series of 8 patients. Case series. Int J Surg [Internet]. 2011 [citado 20 Oct 2020];9:248-53. Disponible en: https://www.sciencedirect.com/science/article/pii/S1743919110005030?via%3Dihub

20. Washington MK, Tang LH, Berlin J, Branton PA, Burgart LJ, Carter DK, et al. Members of the Cancer Committee, College of American Pathologists. Protocol for the examination of specimens from patients with neuroendocrine tumor (carcinoid tumor) of the small intestine and ampulla. Arch Pathol Lab Med [Internet]. 2010 [citado 20 Oct 2020];134:181-6. Disponible en: https://www.archivesofpathology.org/doi/10.1043/1543-2165-134.2.181?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

21. Levy AD, Taylor LD, Abbott RM, Sobin LH. Duodenal carcinoids: imaging features with clinical-pathologic comparison. Radiology [Internet]. 2005 [citado 20 Oct 2020];237:967-72. Disponible en: https://pubs.rsna.org/doi/10.1148/radiol.2373041863?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

22. Modlin IN, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumours. Cancer [Internet]. 2003 [citado 20 Oct 2020];97:934-59. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1002/cncr.11105

23. Koopmans KP, Neels ON, Kema IP, Elsinga PH, Links TP, de Vries EG, Jager PL. Molecular imaging in neuroendocrine tumors: molecular uptake mechanisms and clinical results. Crit Rev Oncol Hematol [Internet]. 2009 [citado 20 Oct 2020];71:199-213. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1040842809000493?via%3Dihub

24. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, et al. One hundred years after carcinoid: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol [Internet]. 2008 [citado 20 Oct 2020];26(18):3063-3072. Disponible en: https://ascopubs.org/doi/full/10.1200/JCO.2007.15.4377?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Published

2020-12-02

How to Cite

1.
Piamo-Morales AJ, Ferrer-Marrero D, Chávez-Jiménez D, Wilson-Batista E. Carcinoid tumor of the duodenum: a rare and interesting incidental finding. Arch méd Camagüey [Internet]. 2020 Dec. 2 [cited 2025 Aug. 28];24(6):880-9. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/6814

Issue

Section

Case Reports