Usefulness of the serological diagnosis of Helicobacter Pylori in patients with gastroduodenal ulcer

Authors

  • Guillermo Brito Adán
  • Odalys Irmina Rodríguez Heredia
  • Elizabeth Nicolau Pestana
  • Yosvany Rojas Peláez
  • Yon Luis Trujillo Pérez

Abstract

Background: Helicobacter Pylori infection is the main cause of gastroduodenal ulcer disease.
Objective: to determine the usefulness of Helicobacter Pyloriserological diagnosis in patients with gastroduodenal ulcer.
Methods: a longitudinal, prospective, analytical study was carried out with the purpose of describing the serological diagnosis of Helicobacter Pyloriin patients with gastroduodenal ulcer at the Manuel Ascunce Domenech hospital from July 1st, 2015 to July 31st, 2016. The universe of study that consisted of 104 patients diagnosed with gastroduodenal ulcer who met the inclusion criteria. A survey of all patients was conducted which was validated by expert criteria. For the implementation of the study, communication with the patients was established aimed at ensuring their participation in this research, which was validated through informed consent.
Results: in the research there was a high incidence of Helicobacter Pylori infection in the age group from 40-49 years. The majority of infected patients were female. In the cases studied, the clinical manifestations that predominated were: epigastrium pain and dyspepsia.
Conclusions: the usefulness of serological diagnosis is due to the fact that this noninvasive technique for detecting the antibody against Helicobacter Pyloriinfection is highly sensitive, showing values of 0,93 and a low specificity with values of 0,05.

DeCS: SEROLOGIC TESTS; HELICOBACTER PYLORI; PEPTIC ULCER; ABDOMINAL PAIN; LONGITUDINAL STUDIES.

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References

1.Camilo SM, Almeida EC, Miranzi BA, Silva JC, Nomelini RS, Etchebehere RM. Endoscopic and histopathologic gastric changes in chronic users of proton-pump inhibitors. Arq Gastroenterol. 2015 Ene-Mar;52(1):59-64.

2.Steer HW. Ultraestructure of cell migration through the gastric epithelium and its relationship to bacteria. J Clin Pathol. 1975;28(1):639-46.

3.Gisbert JP, Calvet X, Bermejo F, Boixeda D, Bory F, Bujanda L, et al. III Conferencia Española de Consenso sobre la infección por Helicobacter pylori. Gastroenterol Hepatol. 2013;36(5):340-53.

4.Ruiz Domínguez R, Huanca Poma A. Prevalencia de infección por h. pylori en una población de nivel socioeconómico medio y alto. Rev Méd La Paz. 2013;19(1):2-6.

5.Gutiérrez Carrillo B, Sierra González G, Valmaña Sánchez CE, Valdés Aonso L, Ricardo Fonseca ME, Calderón Samé LM. Infección por Helicobacter pylori en pacientes dispépticos y en pacientes VIH+. Rev Cubana Invest Bioméd. Jul-Sep 2010;29(3):345-52.

6.Myint T, Shiota S, Vilaichone RK, Ni N, Aye TT, Matsuda M, et al. Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar. World J Gastroenterol. 2015 Ene 14;21(2):629-36.

7.Makhlough A, Fakheri H, Farkhani AR, Seddighi O, Hossieni SV, Khademloo M, et al. A comparison between standard triple therapy and sequential therapy on eradication of Helicobacter pylori in uremic patients: A randomized clinical trial. Adv Biomed Res. 2014;3(1):248-52.

8.Wang YC, Chen CL, Sheu BS, Yang YJ, Tseng PC, Hsieh CY, et al. Helicobacter pylori infection activates Src homology-2 domain-containing phosphatase 2 to suppress IFN-gamma signaling. J Immunol. 2014 Oct 15;193(8):4149-58.

9.Nguyen TL, Uchida T, Tsukamoto Y, Trinh DT, Ta L, Mai BH, et al. Helicobacter pylori infection and gastroduodenal disease in Vietnam: a cross-sectional, Hospital-based study. BMC Gastroenterol. 2010 Sep 30;10:114-20.

10.Montes de Oca Megías E, Noa Pedroso GR, Agüero Betancourt C de los M, Seijas Cabrera O, Pérez Triana F, García Jordá E. Comportamiento de la infección por Helicobacter pylori en la úlcera gastroduodenal en una comunidad venezolana. Arch Med Camagüey. May-Jun 2013;17(3):1-3.

11.Suárez Rivera JJ, Almaguer Betancourt YM. Caracterización clínica-epidemiológica de la úlcera gastroduodenal por helicobacter pylori en el municipio Urdaneta. Med fam Andal. Jul 2013;4(2):161-65.

12.Osorio Pagola MF, Olivert Cruz MB, Pasos Carrazana JL de, Quiñones Ceballo AB, Vega Galindo M, Ortega Avelay A. Caracterización de la infección por Helicobacter pylori en pacientes con úlcera gástrica. MediSur. Nov-Dic 2009;7(6):3-11.

13.Monteiro L, Gras N, Vidal R, Cabrita J, Megraud F. Detection of Helicobacter pylori DNA in human feces by PCR: DNA stability and removal of inhibitors. J Microbiol Methods. 2001;45:89-94.

14.Javier PG, Calvet X, Bermejo F, Boixeda D, Bory F, Bujanda L. III Conferencia Española de Consenso sobre la infección por Helicobacter pylori. Gastroenterol Hepatol. 2013;36(5):340-74.

15.Alonso Soto J, Rodríguez González BL, Moreno Guerra A, Chao González L. Evaluación de la utilidad de diferentes métodos para el diagnóstico de Helicobacter pylori. Rev Cubana Invest Bioméd. Ene-Mar 2013;32(1):1-13.

16.Archila P, Tovar L, Ruiz M. Características histológicas de la gastritis crónica y otros métodos diagnósticos reportadas en las biopsias gástricas de niños de 1 a 16 años de edad en el Hospital Infantil de San José, durante el período comprendido entre septiembre de 2008 a septiembre de 2010. Rev Col Gastroenterol. Abr-Jun 2012;27(2):12-15.

17.Quintana EM, Salas CP, Achí AR, Davidovich RH, Schosinsky NK. Valor diagnóstico de anticuerpos anti Helicobacter pylori en pacientes referidos al Servicio de Endoscopia Digestiva del Hospital San Vicente de Paul, Costa Rica. Rev Biomed. 2002;13(1):15-23.

18.Ansari SA, Khan A, Khan TA, Raza Y, Syed SA, Akhtar SS, et al. Correlation of ABH blood group antigens secretion with Helicobacter pylori infection in Pakistani patients. Trop Med Int Health. 2015 Ene;20(1):115-9.

19.Qing QI, Xiu LZ, Hang LI, Rui JI, Zhen LI, Cheng JZ, et al. High-definition magnifying endoscopy with i-scan in the diagnosis of Helicobacter pylori infection: A pilot study. J Dig Dis. 2013 Nov;14(11):579-86.

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Published

2018-03-30

How to Cite

1.
Brito Adán G, Rodríguez Heredia OI, Nicolau Pestana E, Rojas Peláez Y, Trujillo Pérez YL. Usefulness of the serological diagnosis of Helicobacter Pylori in patients with gastroduodenal ulcer. Arch méd Camagüey [Internet]. 2018 Mar. 30 [cited 2025 Jul. 16];22(2):214-23. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/5569

Issue

Vol. 22 No. 2 (2018)

Section

Original Articles

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