Prescription patterns characteristics of new antiepileptic drugs
Keywords:
CONVULSIONES, EPILEPSIA, ANTICONVULSIVANTES, ESTUDIO OBSERVACIONAL.Abstract
Background: epilepsy is one of the most frequent neurological diseases and almost 30 % of patients who suffer from it do not get control with classic antiepileptic drugs.
Objective: to characterize prescription patterns of new antiepileptic drugs in Camagüey municipality.
Methods: a descriptive and cross-section study about use of medicines, of prescription-indication type with elements of therapeutic scheme was conducted. The study universe was composed of 300 patients and all of them were included in the research. The following variables were studied: group of age, indications, associations and interval of administration.
Results: the use of vigabatrin and lamotrigin prevailed in children and patients with diagnosis of epilepsy while the Gabapentin was more frequent used in adults and neuropathic pain. Vigabatrin and lamotrigin were mainly used in associations with classical antiepileptic drugs, being valproic acid the most used drug on it. Gabapentin was used alone. There were mistakes on intervals of administration of all studied drugs.
Conclusions: the prescription of new antiepileptic drugs was adequate in most cases. Identified mistakes were related to intervals of administration.
DeCS: DRUG PRESCRIPTIONS; SEIZURES; ANTICONVULSANTS; NERVOUS SYSTEM DISEASES; EPIDEMIOLOGY, DESCRIPTIVE.
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1.Martín Zurro A. Atención primaria. Problemas de salud en la consulta de medicina de familia. 7a ed [Internet]. España: Elsevier S.L.; 2014 [citado 12 Ago 2014]. Disponible en: https://www.clinicalkey.es/#!/content/book/3-s2.0-B9788490221105000269?scrollTo=%23s0370
2.Goldman L, Schafer A, editores. Tratado de Medicina interna. 25a ed [Internet]. España: Elsevier S. L; 2016 [citado 12 Dic 2016]. Disponible en: https://www.clinicalkey.es/#!/content/book/3-s2.0-B9781455750177004037
3.Daroff R, Jankovic J, Mazziotta J, Pomeroy S, editors. Bradley's Neurology in Clinical Practice. 7a ed [Internet]. España: Elsevier Inc.; 2016 [cited 2016 Dec 12]. Available from: https://www.clinicalkey.es/#!/content/book/3-s2.0-B9780323287838001010?scrollTo=%23s0010
4.Mikati MA, Hani AJ. Seizures in Childhood. In: Kliegman R, Station B, St Geme J, Schor N, editors. Nelson Textbook of Pediatrics. 20 th ed [Internet]. España: Elsevier, Inc.; 2016 [cited 2016 Dec 12]. Available from: https://www.clinicalkey.es/#!/content/book/3-s2.0-B9781455775668005937
5.Valdivia Álvarez I, Abadal Borges G. Epilepsia de difícil control en Pediatría. Nuevas drogas antiepilépticas. Rev Cubana Pediatr [Internet]. Jul-Dic 2005 [citado 12 Ago 2014];77(3):[aprox. 12 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S003475312005000300008&lng=es&nrm=iso
6.Sosa Sánchez TM. Epilepsia. En: Vicente Peña E, Rodríguez Porto AL, Sánchez Zulueta E, Quintana López L, Riverón González JM, Ledo Grogués D, editores. Diagnóstico y tratamiento en Medicina Interna. La Habana: ECIMED; 2012. p. 660-669.
7.Rimbau Cabrera D. Patrón de reacciones adversas a los anticonvulsivantes en niños en la provincia de Camagüey [tesis]. Camagüey: Universidad de Ciencias Médicas de Camagüey; 2012.
8.Farreras Valentí P, Rozman C, editores. Medicina Interna. 17 ed [Internet]. España: Elsevier, S. L; 2012 [citado 22 Ene 2016]. Disponible en: https://www.clinicalkey.es/#!/content/book/3-s2.0-B9788480868969001680
9.Kros L, Eelkman O, De Zeeuw C, Hoebeek FE. Controlling Cerebellar Output to Treat Refractory Epilepsy. Trends in Neurosciences [Internet]. 2015 Dec 1 [cited 2016 Jan 22];38(12):[about 12 p.]. Available from: https://www.clinicalkey.es/#!/content/journal/1-s2.0-S016622361500226X
10.Auvin S. Antiepilépticos. EMC–Pediatría [Internet]. 2014 [citado 22 Ene 2016];49(1):[aprox. 12 p.]. Disponible en: http://dx.doi.org/10.1016/S1245-1789(14)67013-X
11.Gómez Betancur L, Vilaplana Domínguez L, Sancho Rieger J. Tratamiento de la epilepsia. Programa de Formación Médica Continuada Acreditado. Medicine [Internet]. 1 Mar 2015 [citado 12 Ago 2015];11(73):[aprox. 10 p.]. Disponible en: https://www.clinicalkey.es/#!/browse/journal/03045412/1-s2.0-S0304541215X70934
12.Pozo Lauzán D, Pozo Alonso A. Antiepilépticos de tercera generación. Rev Cubana Pediatr [Internet]. Ene-Mar 2010 [citado 12 Ago 2014];82(1):[aprox. 3 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S003475312010000100010&lng=es&nrm=iso
13.Pozo Alonso AJ, Pozo Lauzán D. Tratamiento con medicamentos antiepilépticos en el niño. Rev Cubana Pediatr [Internet]. Oct-Dic 2013 [citado 12 Ago 2014];85(4):[aprox. 10 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S003475312013000400010&lng=es&nrm=iso
14.Ministerio de Salud Pública. Cuadro básico de Medicamentos. La Habana: ECIMED; 2014. Medicamentos dispensados por tarjeta control; p. 14.
15. Ministerio de Salud Pública. Cuadro básico de Medicamentos. La Habana: ECIMED; 2014. Medicamentos por certificado médico; p. 20.
16.Ministerio de Salud Pública. Formulario Nacional de Medicamentos. 4ta ed. La Habana: ECIMED; 2014. Anticonvulsivos; p. 71-91.
17.Trevathan E, Kerls SP, Hammer AE, Vuong A, Messenheimer JA. Lamotrigine adjunctive therapy among children and adolescents with primary generalized tonic-clonic seizures. Pediatrics [Internet]. 2006 Aug [cited 2014 Aug 12];118(2):[about 9 p.]. Available from: https://www.clinicalkey.es/#!/content/medline/2-s2.0-16847080
18.Hussain K, Walsh TJ, Chazen JL. Brain MRI findings with vigabatrin therapy: case report and literature review. Clin Imaging [Internet]. 2016 Ene-Feb [cited 2016 Mar 1];40(1):[about 3 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26526789
19.Chen L, Mao J. Medicamentos analgésicos no opioides. En: Miller RD, Cohen NH, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Young WL, editores. Miller. Anestesia. España: Elsevier, S.L.U.; 2016. p. 1-17.
20.Caminero Rodríguez AB. Dolor neuropático y neuralgias craneofaciales. En: Serra Catafau J, editor. Tratado de dolor neuropático [Internet]. Madrid: Editorial Médica Panamericana, S.A.; 2007 [citado 22 Feb 2016]. Disponible en: https://www.clinicalkey.es/#!/content/book/3-s2.0-B9788445820087500055
21.McNamara JO. Farmacoterapia de las epilepsias. En: Brunton L, Chabner B, Knollmann B, editors. Goodman y Gilman. Las bases farmacológicas de la terapéutica. 12a ed. México D.F: McGraw-Hill Interamericana; 2012. p. 583-606.
22.Morales Plaza CD, Machado Alba JE. Patrones de prescripción de antiepilépticos en pacientes colombianos afiliados al Sistema General de Seguridad Social en Salud. Neurología [Internet]. 2014 [citado 22 Feb 2016]32(1):[aprox. 9 p.]. Disponible en: https://www.clinicalkey.es/#!/content/journal/1-s2.0-S0213485314002011
23.Xiao Y, Gan L, Wang J, Luo M, Luo H. Vigabatrin versus carbamazepine monotherapy for epilepsy. Cochrane Database Syst Rev [Internet]. 2015 [cited 2016 Jan 19];11:[about 7 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26580100
24.Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, et al. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet [Internet]. 2007 Mar 24 [cited 2016 Jan 19];369(9566):[about 15 p.]. Available from: https://www.clinicalkey.es/#!/content/medline/2-s2.0-17382827
25.Kwan P, Brodie MJ, Kälviäinen R, Yurkewicz L, Weaver J, Knapp LE. Efficacy and safety of pregabalin versus lamotrigine in patients with newly diagnosed partial seizures: a phase 3, double-blind, randomised, parallel-group trial. Lancet Neurol [Internet]. 2011 Oct 1 [cited 2016 Jan 19];10(10):[about 9 p.]. Available from: https://www.clinicalkey.es/#!/content/medline/2-s2.0-21889410
26.Zeng QY, Fan TT, Zhu P, He RQ, Bao YX, Zheng RY, et al. Comparative Long-Term Effectiveness of a Monotherapy with Five Antiepileptic Drugs for Focal Epilepsy in Adult Patients: A Prospective Cohort Study. PLoS One [Internet]. 2015 [cited 2016 Jan 19];10(7):[about 7 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26147937
27.Valdivia Álvarez I, Garnelo Loaeza M, Bonet Quesada E, Odales Ibarra R, García García R, Marrero Martínez P. Eficacia de la vigabatrina en la epilepsia refractaria del niño. Rev Cubana Pediatr [Internet]. Jul-Sep 2007 [citado 12 Ago 2014];79(3):[aprox. 12 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S003475312007000300005&lng=es&nrm=iso&tlng=es
28.Armijo Simon JA, Herranz Fernández JL. Fármacos antiepilépticos y anticonvulsivantes. En: Flórez Beledo J, Armijo Simon JA, Mediavilla Martínez A, editores. Farmacología Humana. 6ta ed. Elsevier España S.L.; 2014. p. 476-502.
29.Inoue K, Yamamoto Y, Suzuki E, Takahashi T, Umemura A, Takahashi Y, et al. Factors that influence the pharmacokinetics of lamotrigine in Japanese patients with epilepsy. Eur J Clin Pharmacol [Internet]. 2016 May [cited 2016 Feb 19];72(5):[about 3 p.]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26790665

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