Leukoglycaemic index as a predictor in short term of mortality in stroke

Authors

  • Pedro Julio García Álvarez Hospital Militar
  • Ángel Pastor García Albero
  • Jorge Santana Álvarez

Abstract

Background: acute ischemic stroke is the third leading cause of death in the world, the first cause of disability and the second cause of dementia. Nowadays, in emergency medicine, risk markers are sought with the aim of predicting complications, mortality and thus targeting vulnerable patients for more aggressive therapeutic efforts.
Objective:
to test the leucoglycemic index as a prognostic marker of mortality in acute ischemic stroke as well as to calculate the cutoff value.
Methods:
a retrospective longitudinal analytical study was performed in 45 patients admitted to the Emergent Intensive Care Unit for acute ischemic stroke at the Dr. Carlos J. Finlay Military Hospital, from January 2017 to April 2017.
Results:
the population group was formed by 45 patients, 21 men and 24 women. Mortality was 28 %. The leukoglycemic index in the group composed by alive people was 1 355 and in the group of deceased ones was 4 029. The cut-off point of the ROC curve was 2506 for a sensitivity of 92 %.
Conclusions: the leukoglycemic index is a marker of mortality risk in patients with ischemic stroke, and the higher the leukoglycemic index, the higher the index value.

DeCS: GLYCEMIC INDEX; STROKE; MORTALITY; ANALYTICAL METHODS; RISK INDEX.

Downloads

Download data is not yet available.

Author Biography

Pedro Julio García Álvarez, Hospital Militar

Especialista en 1er Grado en Anestesiología y Reanimacion.Diplomado en Cuidados Intensivos y Emergencias. Especialista en 1er Grado en Medicina General.

References

1.Caldas Federico A, Iaconis Campbell J. Valor pronóstico del índice leuco-glucémico en el stroke isquémico agudo [Internet]. Buenos aires: Hospital Bernardino Rivadavia; 2012 [citado 2017 Jul 25]. Disponible en: http://www.barcelo.edu.ar/greenstone/collect/investig/index/assoc/HASH0183.dir/AMA%20Caldas%20Federico%252C%20Iaconis%20Campbell%20Juan.pdf

2.Kumar P, Kumar A, Sagar R, Misra S, Faruq M, Suroliya V, et al. Association between interleukin-6 (G174C and C572G) promoter gene polymorphisms and risk of ischemic stroke in North Indian population: a case-control study. Neurol Res [Internet]. 2016 Jan [cited 2017 Jul 25];38(1):[about 6 p.]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26883819

3.Reyes Prieto M, Echeverría F, Chuquel C, Lange J, Escalante J. Teoría inflamatoria del sca: índice leucoglucémico como factor pronóstico [Internet]. Argentina: Instituto de cardiología de Corrientes; 2013 [citado 1 Jul 2017]. Disponible en: http://www.socacorr.org.ar/wp-content/uploads/2013/04/R30_Cap05_TeoriaInflamantoriaDeSCA.pdf

4.Ryabinkina YV, Gnedovskaya EV, Maksimova MY, Prokazova PR, Gelfand BR, Piradov MA.Stroke: incidence and risk factors for venous thromboembolic complications in intensive care unit. Anesteziol Reanimatol[Internet]. 2015 Sep-Oct; [citado 2017 Jul 25]; 60(5): [about 6 p.]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25065473

5.Díaz Benítez RE, Correa Morales AM, Reyes Hernández LM, Carvajal Sánchez PA, Coronado Herrera Y, González Rivera EM. Hemoglobina glucosilada e índice leucoglucémico como determinaciones pronósticas en el síndrome coronario agudo. Cor Salud [Internet]. Jul-Sep 2016 [citado 1 Jul 2017];8(3):[aprox. 10 p.]. Disponible en: http://www.revcorsalud.sld.cu/index.php/cors/article/view/135/322

6.Quiroga Castro W, Conci E, Zelaya F, Isa M, Pacheco G, Sala J, et al. Estratificación del riesgo en el infarto agudo de miocardio según el índice leucoglucémico. ¿El "Killip-Kimball" de laboratorio? Rev Fed Arg Cardiol [Internet]. 2010 [citado 1 Jul 2017];39(1):[aprox. 6 p.]. Disponible en: http://www.fac.org.ar/1/revista/10v39n1/art_orig/arorig01/quiroga.pdf

7.Cantarini Echezarreta M, Álvarez Correa M, Lombardi M, Martínez L, Pazos Redondo C, Suárez C, et al. Índice leucoglucémico como marcador pronóstico de evolución intrahospitalaria en insuficiencia cardiaca aguda. Rev CONAREC [Internet]. 2017 [citado 1 Jul 2017];32(134):[aprox. 4 p.]. Disponible en: http://adm.meducatium.com.ar/contenido/articulos/5801020106_365/pdf/5801020106.pdf

8.Infomed [Internet]. La Habana: Anuario Estadístico de Salud. 2012; 2013 [actualizado 2017 Mar 12; citado 2017 May 25]. Cuadro 14. Principales causas de muerte en todas las edades. 2000, 2012-2013 [aprox. 2 pantallas]. Disponible en: http://www.sld.cu/sitios/dne/.

9.Faraji F, Talaei z, Eshrati B, Pirasteh S. The evaluation of correlation between plasma level of crp and wbc with ischemic stroke severity and infarct volume. AMUJ [Internet]. 2009 winter [cited 2017 Jul 25];11(4):[about 7 p.]. Available from: http://en.journals.sid.ir/ViewPaper.aspx?ID=138853

10.Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-Lymphocyte Ratio Predicts the Outcome of Acute Intracerebral Hemorrhage. Stroke [Internet]. 2016 Jun [cited 2017 Jul 25];47(6):[about 4 p.]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27165957

11.Maestrini I, Strbian D, Gautier S, Haapaniemi E, Moulin S, Sairanen T. Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes. Neurology [Internet]. 2015 Oct 20 [cited 2017 Jul 25];85(16):[about 8 p.]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26362283

12.Whiteley W, Jackson C, Lewis S, Lowe G, Rumnley A, Sandercock P. Inflammatory Markers and Poor Outcome after Stroke: A Prospective Cohort Study and Systematic Review of Interleukin-6. Plos Medicine [Internet]. 2009 Sep 8 [cited 2017 Jul 25];6(9):[about 8 p.]. Available from: http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000145

13.Aouacheri O, Saka S, Krim M, Messaadia A, Maidi I. The investigation of the oxidative stress-related parameters in type 2 diabetes mellitus. Can J Diabetes [Internet]. 2015 Feb [cited 2017 Jul 25];39(1):[about 5 p.]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25065473

14.Mayer F, Binder C, Wagner O, Schillinger M, Minar E, Mlekusch W. Combined Effects of Inflammatory Status and Carotid Atherosclerosis: A 12-Year Follow-Up Study. Stroke [Internet]. 2016 Dec [cited 2017 Jul 25];47(12):[about 7 p.]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27803393

15.Ascaso J. Leuko-glycaemic index in ST elevation acute myocardial infarction, a simple and useful parameter in the predicting complications. Clin Investig Arterioscler [Internet]. 2014 Jul-Aug [cited 2017 Jul 25];26(4):[about 2 p.]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25066430

16.León-Aliz E, Moreno-Martínez F, Pérez-Fernández G, Vega-Fleites L, Rabassa-López-Calleja M. Leuko-glycemic index as an in-hospital prognostic marker in patients with ST-segment elevation myocardial infarction. Clin Investig Arterioscler [Internet]. 2014 Jul-Aug [cited 2017 Jul 25];26(4):[about 8 p.]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24565746

Published

2018-03-30

How to Cite

1.
García Álvarez PJ, García Albero Ángel P, Santana Álvarez J. Leukoglycaemic index as a predictor in short term of mortality in stroke. Arch méd Camagüey [Internet]. 2018 Mar. 30 [cited 2025 Jul. 15];22(2):163-70. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/5445

Issue

Section

Original Articles