Association between serum amyloid A pathologic levels and periodontitis

Authors

  • Carlos Martín Ardila Medina Universidad de Antioquia

Abstract

Background: serum amyloid A protein is produced in response to the cytokines released by monocytes and macrophages after an acute-phase stimulus such as infection. Objective: to determine the serum levels of amyloid A protein and its association with patients diagnosed with chronic periodontal disease.
Methods: a cross-sectional observational study was conducted. The universe was composed of 80 patients with chronic periodontitis and 28 people without periodontal affections as a control group. Diagnosis of chronic periodontal disease was based on criteria stated previously. All the participants answered a questionnaire related to sociodemographic characteristics. A clinical enzymatic trial was carried out to calculate the levels of pathological serum amyloid A.
Results: pathological levels of serum amyloid A were associated with periodontitis (p = 0,002) and were correlated significantly with older age (r = 2, 42; p= 0, 01). Nevertheless, logistic regression adjusted by age showed remarkable statistical association only with periodontal disease (OR = 5, 6; interval from 95 % 1, 7-19).
Conclusions: probability of presenting pathological levels of serum amyloid A in patients with chronical periodontal disease is six times the one of the patients without this affection. That could me a risk factor for cardiovascular diseases.

DeCS: SERUM AMYLOID A PROTEIN; CHRONIC PERIODONTITIS; CLINICAL ENZYME TESTS; RISK FACTORS; OBSERVATIONAL STUDY.

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Published

2016-10-25

How to Cite

1.
Ardila Medina CM. Association between serum amyloid A pathologic levels and periodontitis. Arch méd Camagüey [Internet]. 2016 Oct. 25 [cited 2025 Aug. 3];20(5):470-6. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/4493

Issue

Vol. 20 No. 5 (2016)

Section

Original Articles

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