Surgical treatment of choledochal cysts in adults: indications and current techniques

Authors

Abstract

Introduction: Choledochal cysts are rare in adults, but early diagnosis is crucial because of the risk of serious complications, including malignant transformation. Thanks to advances in diagnostic and surgical techniques, the prognosis has significantly improved.

Objective: to critically review the current evidence on the surgical treatment of choledochal cysts in adults.

Method: A review of the scientific literature was conducted using PubMed, Scielo, and Science Direct databases. The search included publications in Spanish and English from January 2015 to April 2025. A total of 83 articles were identified; after applying inclusion and exclusion criteria, 42 articles were included in the analysis, of which 35 were ultimately used as references.

Results: Choledochal cysts in adults present clinical and surgical features that differ markedly from those in children. Their classification, based on anatomical and morphological criteria, accurately guides the therapeutic approach. The treatment of choice is surgical, with techniques varying according to the type of cyst, the patient’s clinical condition, age, associated comorbidities, and the accumulated experience of the surgical team. Current surgical indications, open, laparoscopic, and robotic techniques are reviewed, along with their outcomes, complications, and recurrence rates. Recent advances, potential benefits, and persistent challenges in long-term postoperative follow-up are also discussed.

Conclusions: The surgical management of choledochal cysts in adults must be individualized according to cyst type and patient characteristics. Complete resection with biliary diversion remains the standard treatment, while minimally invasive techniques are emerging as safe and effective options in specialized centers.

Downloads

Download data is not yet available.

Author Biography

Roberto Lázaro Blanco-Sosa, Universidad de Ciencias Médicas. Hospital Universitario General Calixto García. Servicio de Cirugía General. La Habana, Cuba.

Médico residente de 4to año de Cirugía General (Hospital Universitario General Calixto García) Máster Universitario en Bioética (Universidad Católica de Valencia, 2024) Miembro de la Sociedad Española de Trasplante Hepático y de la Sociedad Mexicana de Cirugía Hepatopancreatobiliar.

References

1. Singham J, Yoshida EM, Scudamore CH. Choledochal cysts: Part 1 of 3: classification and pathogenesis. Can J Surg [Internet]. 2009 [citado 5 May 2025];52(5):434–40. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760004/

2. Soares KC, Arnaoutakis DJ, Kamel I, Rastegar N, Anders R, Adams RB, et al. Choledochal cysts: presentation, clinical differentiation, and management. J Am Coll Surg [Internet]. 2014 [citado 11 Jun 2025];219(6):1167–80. Disponible en: https://doi.org/10.1016/j.jamcollsurg.2014.06.015

3. Diao M, Li L, Cheng W. Role of laparoscopic surgery in management of choledochal cysts. J Pediatr Surg [Internet]. 2012 [citado 17 May 2025];47(9):1755–9. Disponible en: https://doi.org/10.1016/j.jpedsurg.2012.03.064

4. Visser BC, Suh I, Way LW, Kang SM. Congenital choledochal cysts in adults. Arch Surg [Internet]. 2004 [citado 9 Jun 2025];139(8):855–60. Disponible en: https://doi.org/10.1001/archsurg.139.8.855

5. Stringer MD. The role of surgery in the treatment of choledochal cysts. Ann R Coll Surg Engl [Internet]. 2003 [citado 29 May 2025];85(6):379–85. Disponible en: https://doi.org/10.1308/003588403322520768

6. Li L, Liu Y, Cheng W. A review of current diagnosis and management of choledochal cysts. J Pediatr Surg [Internet]. 2021 [citado 7 May 2025];56(2):363–9. Disponible en: https://doi.org/10.1016/j.jpedsurg.2020.10.009

7. Lipsett PA, Pitt HA, Colombani PM, Boitnott JK, Cameron JL. Choledochal cyst disease: a changing pattern of presentation. Ann Surg [Internet]. 1994 [citado 30 May 2025];220(5):644–52. Disponible en: https://doi.org/10.1097/00000658-199411000-00007

8. Jabłońska B. Biliary cysts: a review of current classification, diagnosis and treatment. Clin Res Hepatol Gastroenterol [Internet]. 2012 [citado 12 Jun 2025];36(2):77–84. Disponible en: https://doi.org/10.1016/j.clinre.2011.12.004

9. Moslim MA, Takahashi H, Seifarth FG, Walsh RM. Choledochal cyst disease in adults: a congenital disease with an acquired component. Front Surg [Internet]. 2016 [citado 4 Jun 2025];3:51. Disponible en: https://doi.org/10.3389/fsurg.2016.00051

10. Søreide K, Søreide JA. Bile duct cyst as precursor to biliary tract cancer. Ann Surg Oncol [Internet]. 2007 [citado 6 May 2025];14(4):1200–11. Disponible en: https://doi.org/10.1245/s10434-006-9301-4

11. Todani T, Watanabe Y, Toki A, Urushihara N, Sato Y. Classification of congenital biliary cystic disease: special reference to type Ic and IVa cysts with primary ductal stricture. J Hepatobiliary Pancreat Surg [Internet]. 2003 [citado 31 May 2025];10(5):340–4. Disponible en: https://doi.org/10.1007/s00534-002-0767-0

12. Flanigan DP. Biliary cysts. Ann Surg [Internet]. 1975 [citado 2 Jun 2025];182(5):635–43. Disponible en: https://doi.org/10.1097/00000658-197511000-00021

13. Lal R, Agarwal PN, Sikora SS, Kumar A, Saxena R, Kapoor VK. Hepaticojejunostomy vs hepaticoduodenostomy after excision of choledochal cysts. J Gastrointest Surg [Internet]. 2004 [citado 1 Jun 2025];8(5):590–4. Disponible en: https://doi.org/10.1016/j.gassur.2003.11.024

14. Yamataka A, Lane GJ, Cazares J, Miyano T. Management of choledochal cysts. Curr Opin Pediatr [Internet]. 2000 [citado 14 Jun 2025];12(3):283–7. Disponible en: https://doi.org/10.1097/00008480-200006000-00011

15. Miyano T, Yamataka A. Hepaticoduodenostomy in the treatment of choledochal cysts: is it a valid alternative to Roux-en-Y hepaticojejunostomy? J Pediatr Surg [Internet]. 1996 [citado 3 Jun 2025];31(7):894–6. Disponible en: https://doi.org/10.1016/S0022-3468(96)90545-4

16. Shimozawa N, Ohtsuka M, Ito H, Kimura F, Shimizu H, Togawa A, et al. Risk of subsequent biliary malignancy in patients undergoing cyst excision for congenital choledochal cysts. J Gastrointest Surg [Internet]. 2008 [citado 10 May 2025];12(5):822–8. Disponible en: https://doi.org/10.1007/s11605-007-0264-5

17. Hung MH, Lin LH, Chen DF, Chen CC. Long-term results of hepaticojejunostomy for choledochal cysts. Eur J Pediatr Surg [Internet]. 2007 [citado 8 May 2025];17(2):102–6. Disponible en: https://doi.org/10.1055/s-2007-965951

18. Narayanan SK, Chen Y, Bajaj S, Kabir I, Pyrsopoulos N. Hepaticojejunostomy: indications, techniques and complications. World J Gastrointest Surg [Internet]. 2020 [citado 18 Jun 2025];12(5):201–10. Disponible en: https://doi.org/10.4240/wjgs.v12.i5.201

19. Kobayashi S, Asano T, Yamataka A. Long-term outcome after surgery for choledochal cysts. Pediatr Surg Int [Internet]. 2017 [citado 6 Jun 2025];33(11):1185–9. Disponible en: https://doi.org/10.1007/s00383-017-4179-3

20. Yoon HK, Lee SK, Kim MH, Lee SS, Lee TY, Park DH. Management of remnant intrapancreatic choledochal cysts. Gastrointest Endosc [Internet]. 2007 [citado 13 Jun 2025];66(6):1107–10. Disponible en: https://doi.org/10.1016/j.gie.2007.03.102

21. Yoon HM, Lee JS, Kim JR, Jung AY, Kim H, Kim MJ. Ultrasonography of pediatric choledochal cysts: interobserver agreement and imaging features. Ultrasound Med Biol [Internet]. 2020 [citado 29 May 2025];46(6):1390–6. Disponible en: https://doi.org/10.1016/j.ultrasmedbio.2020.02.013

22. Wang Y, Yu T, Wang Z, Zhang S, Zhang D, Li J. Outcomes of laparoscopic excision of choledochal cyst in adults: a systematic review and meta-analysis. Surg Endosc [Internet]. 2023 [citado 31 May 2025];37(1):45–54. Disponible en: https://doi.org/10.1007/s00464-022-09681-4

23. Zhang W, Wu G, Dong M, Lu Y, Zheng S. Reoperation for postoperative complications of choledochal cysts. World J Gastroenterol [Internet]. 2015 [citado 1 Jun 2025];21(7):2234–9. Disponible en: https://doi.org/10.3748/wjg.v21.i7.2234

24. Lee SE, Jang JY, Lee YJ, Choi DW, Lee WJ, Cho BH, et al. Choledochal cysts in adults: a different disease entity in children? Arch Surg [Internet]. 2011 [citado 5 Jun 2025];146(10):1174–80. Disponible en: https://doi.org/10.1001/archsurg.2011.234

25. Hasan A, Arul GS, Paraskeva M. Choledochal cysts: current trends in management. Ann R Coll Surg Engl [Internet]. 2014 [citado 13 Jun 2025];96(8):562–8. Disponible en: https://doi.org/10.1308/003588414X14055925060532

26. Zhang H, Zhang J, Su H, Sun S, Lin J, Wang C. Robot-assisted excision of choledochal cysts: a systematic review. J Robot Surg [Internet]. 2020 [citado 30 May 2025];14(3):423–30. Disponible en: https://doi.org/10.1007/s11701-019-00966-y

27. Liem NT, Pham HD, Dung le A. Laparoscopic treatment of choledochal cysts in children: lessons learned from 190 cases. J Pediatr Surg [Internet]. 2010 [citado 9 Jun 2025];45(2):540–4. Disponible en: https://doi.org/10.1016/j.jpedsurg.2009.10.022

28. Wang X, Cai Y, Xu Z. Comparison of Roux-en-Y hepaticojejunostomy and hepaticoduodenostomy in children with choledochal cysts. Pediatr Surg Int [Internet]. 2013 [citado 7 Jun 2025];29(2):193–9. Disponible en: https://doi.org/10.1007/s00383-012-3200-7

29. Alonso-Lej F, Rever WB, Pessagno DJ. Congenital choledochal cyst, with a report of 2 and an analysis of 94 cases. Int Abstr Surg [Internet]. 1959 [citado 2 Jun 2025];108(1):1–30. Disponible en: https://pubmed.ncbi.nlm.nih.gov/13617143/

30. Miyano T, Yamataka A, Segawa O, Koga H, Lane GJ. Hepaticoduodenostomy or hepaticojejunostomy after cyst excision in choledochal cysts. J Pediatr Surg [Internet]. 2000 [citado 3 Jun 2025];35(12):1733–6. Disponible en: https://doi.org/10.1053/jpsu.2000.19255

31. Duman L, Şaşmaz N, Ünalp HR, Dalgıç B. Portal hypertension as a complication of type IV-A choledochal cysts. Turk J Gastroenterol [Internet]. 2018 [citado 11 Jun 2025];29(2):226–9. Disponible en: https://doi.org/10.5152/tjg.2018.17440

32. Shah OJ, Robbani I, Zargar SA, Khan F. Type IV-A choledochal cysts: evaluation and management. Hepatobiliary Pancreat Dis Int [Internet]. 2009 [citado 1 Jun 2025];8(4):409–12. Disponible en: https://pubmed.ncbi.nlm.nih.gov/19640740/

33. Tanaka M, Seki M, Matsumoto S, Minami S, Inoue K. Surgical treatment of choledochal cyst. J Hepatobiliary Pancreat Surg [Internet]. 2003 [citado 28 May 2025];10(5):352–5. Disponible en: https://doi.org/10.1007/s00534-002-0769-y

34. Noe B, Nguyen T, Hoch B, Rosen J. Pediatric choledochal cysts: diagnosis and management. Curr Opin Pediatr [Internet]. 2014 [citado 27 May 2025];26(3):350–6. Disponible en: https://doi.org/10.1097/MOP.0000000000000094

Published

2026-05-20

How to Cite

1.
Blanco-Sosa RL, Copo-de Armas JA, Montes-Sevilla LD. Surgical treatment of choledochal cysts in adults: indications and current techniques. Arch méd Camagüey [Internet]. 2026 May 20 [cited 2026 May 23];30:e11117. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/11117

Issue

Section

Review Articles