Application of rectal ozone therapy in patients with chronic kidney disease
Abstract
Introduction: Ozone therapy is one of the therapies used in Natural and Traditional Medicine in Cuba. This procedure, through its mechanisms of action, produces a general antioxidant, analgesic, anti-inflammatory, immunomodulatory, germicidal, and organ-regulating effect. It has demonstrated efficacy in the treatment of acute and chronic conditions, primarily those affecting the musculoskeletal system. Studies have been conducted on its effect as an organ protector in patients with type 2 diabetes mellitus and chronic liver disease; however, the evidence found regarding its application in chronic kidney disease at its different stages is insufficient, both due to a lack of scientific rigor and a limited level of recommendation. Objective: To evaluate the therapeutic response to rectal ozone therapy in two patients with chronic kidney disease. Case report: Two patients with chronic kidney disease, stages 2 and 3, respectively, were presented. A male patient with a history of hypertension, chronic diverticulitis, prostate adenoma surgery, and stage 3 chronic kidney disease, and a female patient with a history of exogenous obesity, type 2 diabetes mellitus, and stage 2 chronic kidney disease, were treated with rectal ozone therapy. Analytical studies and the Karnofsky Performance Status scale were administered before and after therapy. At the end of the treatment period, favorable changes were observed in both patients. Conclusions: Ozone therapy can be considered for the treatment of chronic kidney disease.
Downloads
References
1. Iraizoz Barrios AM, Brito Sosa G, Santos Luna JA, León García G, Pérez Rodríguez JE, Jaramillo Simbaña RM; et al. Detección de factores de riesgo de enfermedad renal crónica en adultos. Rev Cubana Med Gen Integr [Internet]. 2022 [citado 22 Mar 2025];38(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S086421252022000200007&lng=es. Epub 01-Jun-2022.
2. Chipi Cabrera JA, Fernandini Escalona E. Enfermedad renal crónica presuntiva en adultos mayores. Rev colom nefrol [Internet]. 2019 [citado 22 Mar 2025];6 (2): 138-151. Disponible en: https://doi.org/10.22265/acnef.6.2.352.
3. Martínez Ginarte G, Guerra Domínguez E, Pérez Marín D. Enfermedad renal crónica, algunas consideraciones actuales. Multimed [Internet]. 2020[citado 22 Mar 2025];24(2): 464-469. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S102848182020000200464&lng=es
4. Crisol Deza DA, Medeiros Bascope ML. Uso de la ozonoterapia como tratamiento complementario. Rev Cuba Reumatol [Internet]. 2021 [citado 22 Mar 2024]; 23(3): e245. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1817-59962021000300002&lng=es.
5. Hidalgo Tallón FJ. Oxígeno-ozonoterapia: una realidad médica. Rev Soc Esp Dolor [Internet]. 2009 [citado 3 Feb 2024]; 16( 3 ): 190-191. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S113480462009000300007&lng=es.
6. Gavilán Hernández TC. Potencialidades terapéuticas de la ozonoterapia en el Instituto de Hematología e Inmunología. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2022[citado 3 Feb 2024];38(1): e1435. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S086402892022000100001&lng=es.
7. Urgellés Carreras SA, Aguilar Aleaga L, Reyes Guerrero E, Álvarez Fiallo M. Uso de ozonoterapia en las pacientes con enfermedad inflamatoria pélvica aguda Etapa III. Rev Cubana Obstet Ginecol [Internet]. 2019 [citado 22 Mar 2025]; 45 (3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138600X2019000300005&lng=es.
8. Jaramillo Cazco PF, Morales Fiallo DA, González Perdomo GC, Maldonado Salcedo GE. La ozonoterapia potencia la efectividad de la quimioterapia y disminuye sus reacciones adversas, mejorando la calidad de salud en el cáncer epitelial ovárico. Revista médica Risaralda [Internet]. 2024 [citado 22 Mar 2025];30 (2): 155-165. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S012206672024000200155&lng=en.
9. Pérez Reina M, Pérez Reina MC, Rodríguez León JE, Núñez Pérez E, Lamote Matos I, Valero Valero I. Efectividad de la ozonoterapia y la kinesiología en las secuelas de COVID-19. Yaguaramas, 2022. Medisur [Internet]. 2024[citado 22 Mar 2025]; 22(2 ): 219-226. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1727-897X2024000200219&lng=es.
10. Calunga Fernández JL, Zamora Rodríguez Z, Arenas Falcón B, Menéndez Cepero S, García Hernández L, Villena Mayeta I; et al. Efectos protectores de la Ozonoterapia en el daño renal y hepático en la Diabetes Mellitus Tipo 2. Rev. CENIC Cienc. Biol [Internet]. 2021 [citado 22 Mar 2025];52( 1 ): 18-31. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S222124502021000100018&lng=es.
11. Calunga Fernández JL, Bello Ferro M, Chaple La Hoz M, Barber Gutiérrez E, Menéndez Cepero S, Merino N. Ozonoterapia en la glomerulonefritis tóxica experimental por adriamicina. Rev Cubana Invest Bioméd [Internet]. 2004[citado 22 Mar 2025] ;23 (3): 139-143. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002004000300002&lng=es.
12. Delgadillo Valero LF, Hernández Cruz EY, Pedraza Chaverri J. The Protective Role of Ozone Therapy in Kidney Disease: A Review. Life (Basel) [Internet]. 2023 [citado 22 Mar 2025];13(3):752 Disponible en: DOI: 10.3390/life13030752
13. Fernández Iglesias A, González Núñez L, Calunga Fernández JL, Rodríguez Salgueiro S, Santos Febles E. Poscondicionamiento con ozono en un modelo de isquemia-reperfusión renal: Pruebas funcionales y morfológicas. Nefrología (Madr.) [Internet]. 2011 [citado 22 Mar 2025]; 31(4): 464-470. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S021169952011000400011&lng=es.
14. Griffin BR, Faubel S, Edelstein CL. Biomarkers of Drug-Induced Kidney Toxicity. Ther Drug Monit[Internet]. 2019 Apr [cited 3 Feb 2026];41(2):213-226. Available from: http://10.1097/FTD.0000000000000589
15. Bustamante Rojas L, D’Peña Ardaillon F, Durán Agüero S, Tiscornia González C, Aicardi Spalloni V. Evaluación de la calidad de vida de pacientes chilenos en diálisis peritoneal mediante el cuestionario KDQOL-36. Rev méd. Chile [Internet]. 2021 [citado 3 Feb 2026]; 149 (2): 1744-1750. Disponible en:
http://dx.doi.org/10.4067/s0034-98872021001201744.
16. Albañil Frías T, Ramírez Moreno MC, Crespo Montero R. Análisis de la calidad de vida en pacientes en hemodiálisis ambulatoria y su relación con el nivel de dependencia. Enferm Nefrol [Internet]. 2014 [citado 4 May 2025]; 17 (3): 167-174. Disponible en:
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2254-28842014000300002
Published
How to Cite
Issue
Section
License
Copyright (c) 1970 Oscar Eduardo Sánchez Valdeolla, Leonardo Curbelo Rodríguez, yunesxy canales cruz
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright: Camagüey Medical Archive Magazine, offers immediately after being indexed in the SciELO Project; Open access to the full text of the articles under the principle of making available and free the research to promote the exchange of global knowledge and contribute to a greater extension, publication, evaluation and extensive use of the articles that can be used without purpose As long as reference is made to the primary source.
Conflicts of interest: authors must declare in a mandatory manner the presence or not of conflicts of interest in relation to the investigation presented.
(Download Statement of potential conflicts of interest)
The Revista Archivo Médico de Camagüey is under a License Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 International (CC BY 4.0).
This license allows others to distribute, to mix, to adjust and to build from its work, even for commercial purposes, as long as it is recognized the authorship of the original creation. This is the most helpful license offered. Recommended for maximum dissemination and use of licensed materials. The full license can be found at: https://creativecommons.org/licenses/
22 julio 2025