Endothelial function in patients with type II spinocerebellar ataxia

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Abstract

Introduction: Endothelial function in patients with spinocerebellar ataxia type 2 allows us to evaluate the appearance of cardiovascular diseases in this type of patients from an earlier age.
Objective: To characterize endothelial function in patients with spinocerebellar ataxia type 2
Methods: An analytical case-control study was carried out in patients with spinocerebellar ataxia type 2 from June 2021 to June 2023 at the Vladimir Ilich Lenin Hospital in Holguín. The sample was 25 patients in the case group and 25 patients in the control group. They underwent carotid Doppler and flow vasodilation tests and were distributed according to the risk factors with the greatest association with endothelial dysfunction.
Results: 13 patients had endothelial dysfunction, eight (32 %) male and the majority in the age group of 41 to 50 years (33 %), 7 patients (28 %) had increased intima-media thickness. In 28 % of the total it was associated with increased intima media thickness in relation to atherosclerosis. The association with elevated cholesterol and triglyceride levels and obesity predominated, as well as increased intima-media thickness between 5 and 11 % higher than the control group. Male sex predominated (66.7%) in patients with non-atherosclerotic endothelial dysfunction. 66.6 % had an evolution time from 0 to 15 years after diagnosis.
Conclusions: The existence of endothelial dysfunction was demonstrated, both associated and not associated with atherosclerosis, suggesting a relationship between the ataxin 2 mutation and the increased probability of endothelial dysfunction in these patients.
DeCS: SPINOCEREBELLAR ATAXIAS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; RISK FACTORS; ATAXINS.

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References

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2025-04-29

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Pérez-Guerrero JL, Roselló-Zayas I, Hidalgo-Pupo R, Pupo-Herrera L, Lachagtanerais-Popa E. Endothelial function in patients with type II spinocerebellar ataxia. Arch méd Camagüey [Internet]. 2025 Apr. 29 [cited 2025 Jul. 15];29:e10279. Available from: https://revistaamc.sld.cu/index.php/amc/article/view/10279

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